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Gene: Nlrp1a (NLR family, pyrin domain containing 1A) Mus musculus
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Symbol: Nlrp1a
Name: NLR family, pyrin domain containing 1A
Description: Predicted to have scaffold protein binding activity. Involved in several processes, including positive regulation of interleukin-1 beta secretion; programmed necrotic cell death; and response to muramyl dipeptide. Predicted to localize to inflammasome complex and neuronal cell body. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1); PARTICIPATES IN interleukin-1 signaling pathway; NOD-like receptor signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CARD7; caspase recruitment domain protein; caspase recruitment domain-containing protein 7; death effector filament-forming Ced-4-like apoptosis protein; DEFCAP; Gm14; Gm15; NAC; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT/LRR/pyrin domain-containing protein 1; Nalp1; Nalp1a; NLR family, pyrin domain containing 1; NLR family, pyrin domain containing 1A, CAST/EiJ strain specific; NLR family, pyrin domain containing 1A, PWK/PhJ strain specific; NLR family, pyrin domain containing 1A, WSB/EiJ strain specific; Nlrp1; nucleotide-binding domain and caspase recruitment domain; PP1044
Orthologs:
Homo sapiens (human) : NLRP1 (NLR family pyrin domain containing 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nlrp1a (NLR family, pyrin domain containing 1A)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : NLRP1 (NLR family pyrin domain containing 1)
Canis lupus familiaris (dog) : NLRP1 (NLR family pyrin domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrp1 (NLR family pyrin domain containing 1)
Sus scrofa (pig) : NLRP1 (NLR family pyrin domain containing 1)
Chlorocebus sabaeus (African green monkey) : NLRP1 (NLR family pyrin domain containing 1)
more info ...
Related Pseudogenes: Nlrp1c-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1171,092,236 - 71,144,704 (-)EnsemblGRCm38mm10GRCm38
GRCm381171,091,197 - 71,144,969 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371170,904,699 - 70,958,206 (-)NCBIGRCm37mm9NCBIm37
MGSCv361170,908,431 - 70,958,561 (-)NCBImm8
Celera1178,634,796 - 78,688,328 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nlrp1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1623841
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.