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Gene: Fbxw7 (F-box and WD-40 domain protein 7) Mus musculus
Symbol: Fbxw7
Name: F-box and WD-40 domain protein 7
Description: Predicted to have several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; and positive regulation of proteolysis involved in cellular protein catabolic process. Localizes to several cellular components, including the Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in brain; early conceptus; and genitourinary system. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7); PARTICIPATES IN Notch signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110001A17Rik; AGO; Cdc4; F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein Fbxw6; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; Fbw7; Fbwd6; Fbx30; Fbxo30; Fbxw6; SEL-10
Homo sapiens (human) : FBXW7 (F-box and WD repeat domain containing 7)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fbxw7 (F-box and WD repeat domain containing 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fbxw7 (F-box and WD repeat domain containing 7)
Pan paniscus (bonobo/pygmy chimpanzee) : FBXW7 (F-box and WD repeat domain containing 7)
Canis lupus familiaris (dog) : FBXW7 (F-box and WD repeat domain containing 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fbxw7 (F-box and WD repeat domain containing 7)
Sus scrofa (pig) : FBXW7 (F-box and WD repeat domain containing 7)
Chlorocebus sabaeus (green monkey) : FBXW7 (F-box and WD repeat domain containing 7)
Heterocephalus glaber (naked mole-rat) : Fbxw7 (F-box and WD repeat domain containing 7)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl384,815,268 - 84,979,198 (+)Ensembl
GRCm38384,814,990 - 84,979,198 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37384,619,499 - 84,783,120 (+)NCBIGRCm37mm9NCBIm37
MGSCv36385,038,138 - 85,063,561 (+)NCBImm8
Celera384,827,347 - 84,997,996 (+)NCBICelera
Cytogenetic Map3 F1NCBI
cM Map337.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fbxw7
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1624041
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.