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Gene: Tyrobp (TYRO protein tyrosine kinase binding protein) Mus musculus
Symbol: Tyrobp
Name: TYRO protein tyrosine kinase binding protein
CRRD ID: 1624060
Description: Exhibits signaling receptor binding activity. Involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine production; and regulation of lymphocyte activation. Localizes to cell surface. Is expressed in blood vessel; brain; central nervous system; corpus callosum; and embryo. Used to study Nasu-Hakola disease. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP); INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DAP; DAP12; DNAX-activation protein 12; K; KAR-associated protein; KARAP; killer cell activating receptor associated protein; killer-activating receptor-associated protein; Ly83; TYRO protein tyrosine kinase-binding protein
Homo sapiens (human) : TYROBP (transmembrane immune signaling adaptor TYROBP)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tyrobp (transmembrane immune signaling adaptor Tyrobp)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
Pan paniscus (bonobo/pygmy chimpanzee) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Canis lupus familiaris (dog) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
Sus scrofa (pig) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Chlorocebus sabaeus (African green monkey) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Heterocephalus glaber (naked mole-rat) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39730,113,207 - 30,117,007 (+)NCBI
GRCm38730,413,782 - 30,417,582 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,413,760 - 30,417,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv37731,198,807 - 31,202,601 (+)NCBIGRCm37mm9NCBIm37
MGSCv36730,122,548 - 30,126,342 (+)NCBImm8
Celera725,005,487 - 25,009,294 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tyrobp
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1624060
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.