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Gene: Tyrobp (TYRO protein tyrosine kinase binding protein) Mus musculus
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Symbol: Tyrobp
Name: TYRO protein tyrosine kinase binding protein
CRRD ID: 1624060
Description: Exhibits signaling receptor binding activity. Involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine production; and regulation of lymphocyte activation. Localizes to cell surface. Is expressed in blood vessel; brain; central nervous system; corpus callosum; and embryo. Used to study Nasu-Hakola disease. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP); INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DAP; DAP12; DNAX-activation protein 12; K; KAR-associated protein; KARAP; killer cell activating receptor associated protein; killer-activating receptor-associated protein; Ly83; TYRO protein tyrosine kinase-binding protein
Orthologs:
Homo sapiens (human) : TYROBP (transmembrane immune signaling adaptor TYROBP)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tyrobp (transmembrane immune signaling adaptor Tyrobp)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
Pan paniscus (bonobo/pygmy chimpanzee) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Canis lupus familiaris (dog) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
Sus scrofa (pig) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Chlorocebus sabaeus (African green monkey) : TYROBP (transmembrane immune signaling adaptor TYROBP)
Heterocephalus glaber (naked mole-rat) : Tyrobp (transmembrane immune signaling adaptor TYROBP)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,113,207 - 30,117,007 (+)NCBI
GRCm38730,413,782 - 30,417,582 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,413,760 - 30,417,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv37731,198,807 - 31,202,601 (+)NCBIGRCm37mm9NCBIm37
MGSCv36730,122,548 - 30,126,342 (+)NCBImm8
Celera725,005,487 - 25,009,294 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tyrobp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1624060
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.