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Gene: Cyp2a4 (cytochrome P450, family 2, subfamily a, polypeptide 4) Mus musculus
Symbol: Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Description: Predicted to have enzyme binding activity; heme binding activity; and monooxygenase activity. Involved in response to stilbenoid. Predicted to localize to cytoplasmic microtubule and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in nicotine dependence. Is expressed in liver; lung; metanephros; nervous system; and nose. Orthologous to several human genes including CYP2A13 (cytochrome P450 family 2 subfamily A member 13) and CYP2A6 (cytochrome P450 family 2 subfamily A member 6); PARTICIPATES IN caffeine pharmacokinetics pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI893559; Cyp15a1; CYPIIA4; cytochrome P450 2A4; cytochrome P450, 2a4; cytochrome P450-15-alpha; cytochrome P450-IIA3.1; D7Ucla4; testosterone 15-alpha-hydroxylase; testosterone 15alpha-hydroxylase
Related Pseudogenes: Cyp2a21-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl726,307,169 - 26,315,088 (+)EnsemblGRCm38mm10GRCm38
GRCm38726,307,192 - 26,315,088 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37727,092,211 - 27,100,107 (+)NCBIGRCm37mm9NCBIm37
MGSCv36726,015,952 - 26,023,848 (+)NCBImm8
Celera720,896,679 - 20,902,855 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cyp2a4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1624100
Created: 2007-05-02
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.