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Gene: FTO (FTO alpha-ketoglutarate dependent dioxygenase) Homo sapiens
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Symbol: FTO
Name: FTO alpha-ketoglutarate dependent dioxygenase
Description: Exhibits DNA-N1-methyladenine dioxygenase activity; demethylase activity; and ferrous iron binding activity. Involved in several processes, including mRNA destabilization; nucleic acid metabolic process; and regulation of brown fat cell differentiation. Localizes to the cytoplasm and nuclear speck. Implicated in obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AlkB homolog 9; ALKBH9; alpha-ketoglutarate-dependent dioxygenase FTO; BMIQ14; fat mass and obesity associated; fat mass and obesity-associated protein; FTO, alpha-ketoglutarate dependent dioxygenase; GDFD; KIAA1752; m6A(m)-demethylase FTO; MGC5149; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; tRNA N1-methyl adenine demethylase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
Orthologs:
Mus musculus (house mouse) : Fto (fat mass and obesity associated)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fto (FTO, alpha-ketoglutarate dependent dioxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fto (FTO alpha-ketoglutarate dependent dioxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : FTO (FTO alpha-ketoglutarate dependent dioxygenase)
Canis lupus familiaris (dog) : FTO (FTO alpha-ketoglutarate dependent dioxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fto (FTO alpha-ketoglutarate dependent dioxygenase)
Sus scrofa (pig) : FTO (FTO alpha-ketoglutarate dependent dioxygenase)
more info ...
Related Pseudogenes: FTOP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381653,703,963 - 54,121,941 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371653,737,875 - 54,148,379 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361652,295,376 - 52,705,882 (+)NCBINCBI36hg18NCBI36
Celera1638,252,466 - 38,662,847 (+)NCBI
Cytogenetic Map16q12.2NCBI
HuRef1639,624,702 - 40,035,200 (+)NCBIHuRef
CHM1_11655,145,011 - 55,555,415 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated

Genomics

Comparative Map Data
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miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on FTO
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1625089
Created: 2007-05-19
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.