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Gene: SCX (scleraxis bHLH transcription factor) Homo sapiens
Symbol: SCX
Name: scleraxis bHLH transcription factor
Description: Exhibits bHLH transcription factor binding activity and protein heterodimerization activity. Contributes to E-box binding activity. Involved in transcription, DNA-templated. Localizes to the nucleus and transcription factor complex; INTERACTS WITH 17beta-estradiol; resveratrol; valproic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: basic helix-loop-helix transcription factor scleraxis; bHLHa41; bHLHa48; bHLHa48; class A basic helix-loop-helix protein 41; class A basic helix-loop-helix protein 48; class II bHLH protein scleraxis; scleraxis basic helix-loop-helix transcription factor; scleraxis homolog A; scleraxis homolog A (mouse); scleraxis homolog B; SCXA; SCXB
Mus musculus (house mouse) : Scx (scleraxis)  MGI  Alliance
Rattus norvegicus (Norway rat) : Scx (scleraxis bHLH transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scx (scleraxis bHLH transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : SCX (scleraxis bHLH transcription factor)
Canis lupus familiaris (dog) : SCX (scleraxis bHLH transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scx (scleraxis bHLH transcription factor)
Sus scrofa (pig) : SCX (scleraxis bHLH transcription factor)
Chlorocebus sabaeus (African green monkey) : SCX (scleraxis bHLH transcription factor)
Heterocephalus glaber (naked mole-rat) : Scx (scleraxis bHLH transcription factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: In the NCBI Build GRCh37 reference assembly SCXA and SCXB are duplicate genes in close proximity to each other on chromosome 8. In August, 2010 the Genome Reference Consortium determined that the region contains a duplication error. The clone on which SCXA was based (AC110280.8) was be removed from the GRCh38 reference assembly and SCXB was retained and renamed to SCX. [27 Sep 2015]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8144,266,453 - 144,268,481 (+)EnsemblGRCh38hg38GRCh38
GRCh388144,265,060 - 144,268,483 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,321,517 - 145,323,045 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,393,505 - 145,395,033 (+)NCBINCBI36hg18NCBI36
Celera8141,665,524 - 141,666,939 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,605,530 - 140,607,095 (+)NCBIHuRef
CHM1_18145,595,226 - 145,596,688 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SCX
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1625822
Created: 2007-07-06
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.