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Gene: SSX2B (SSX family member 2B) Homo sapiens
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Symbol: SSX2B
Name: SSX family member 2B
Description: The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 6757, located about 45 kb upstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cancer/testis antigen 5.2; cancer/testis antigen family 5, member 2b; CT5.2; CT5.2b; HOM-MEL-40; SSX; SSX2; synovial sarcoma, X breakpoint 2; synovial sarcoma, X breakpoint 2B; tumor antigen HOM-MEL-40
Orthologs:
No known orthologs. homologs ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X52,751,204 - 52,761,536 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X52,780,281 - 52,790,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X52,798,483 - 52,807,211 (+)NCBINCBI36hg18NCBI36
Cytogenetic MapXp11.22NCBI
HuRefX49,853,190 - 49,863,501 (-)NCBIHuRef
CHM1_1X52,681,394 - 52,780,715 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SSX2B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1626582
Created: 2007-08-10
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.