Egln2 (egl-9 family hypoxia inducible factor 2) - Chinchilla Research Resource Database
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Gene: Egln2 (egl-9 family hypoxia inducible factor 2) Heterocephalus glaber
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Symbol: Egln2
Name: egl-9 family hypoxia inducible factor 2
CRRD ID: 18916906
Description: ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (ortholog); ferrous iron binding (ortholog); oxygen sensor activity (ortholog); INVOLVED IN cell redox homeostasis (ortholog); peptidyl-proline hydroxylation to 4-hydroxy-L-proline (ortholog); positive regulation of protein catabolic process (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH nicotine dependence (ortholog); renal cell carcinoma (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: egl nine homolog 2; Egl nine-like protein 2
Orthologs:
Homo sapiens (human) : EGLN2 (egl-9 family hypoxia inducible factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Egln2 (egl-9 family hypoxia-inducible factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Egln2 (egl-9 family hypoxia-inducible factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln2 (egl-9 family hypoxia inducible factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Canis lupus familiaris (dog) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln2 (egl-9 family hypoxia inducible factor 2)
Sus scrofa (pig) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Chlorocebus sabaeus (African green monkey) : EGLN2 (egl-9 family hypoxia inducible factor 2)
more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View


Cellular Component
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625  


Genomics

Comparative Map Data
Egln2
(Heterocephalus glaber - naked mole-rat)
No map positions available.
EGLN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1940,798,996 - 40,808,434 (+)EnsemblGRCh38hg38GRCh38
GRCh381940,799,191 - 40,808,434 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371941,305,048 - 41,314,346 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,996,888 - 46,006,177 (+)NCBINCBI36hg18NCBI36
Build 341945,996,984 - 46,006,176NCBI
Celera1938,105,456 - 38,114,745 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1937,738,282 - 37,747,581 (+)NCBIHuRef
CHM1_11941,304,720 - 41,314,010 (+)NCBICHM1_1
Egln2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,858,083 - 26,866,227 (-)NCBI
GRCm38727,158,658 - 27,166,802 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,158,658 - 27,166,802 (-)EnsemblGRCm38mm10GRCm38
MGSCv37727,943,677 - 27,951,821 (-)NCBIGRCm37mm9NCBIm37
MGSCv36726,867,418 - 26,875,665 (-)NCBImm8
Celera721,735,529 - 21,743,673 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.83NCBI
Egln2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0183,969,456 - 83,977,665 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,969,457 - 83,977,236 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,180,394 - 85,188,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,233,239 - 82,240,990 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,311,350 - 82,318,466 (-)NCBI
Celera176,864,947 - 76,872,062 (-)NCBICelera
Cytogenetic Map1q21NCBI
Egln2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578548,578 - 557,609 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955578541,723 - 557,609 (-)NCBIChiLan1.0ChiLan1.0
EGLN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11946,348,912 - 46,357,875 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,349,131 - 46,357,875 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01937,842,460 - 37,851,465 (+)NCBI
EGLN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1112,992,780 - 113,000,677 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11112,992,779 - 113,001,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Egln2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366613,061,391 - 3,070,219 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGLN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1649,002,266 - 49,010,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,685,765 - 44,694,868 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGLN2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl635,251,237 - 35,260,040 (+)Ensembl
ChlSab1.1635,251,247 - 35,263,717 (+)NCBI


Expression


Sequence


Protein Sequences
Protein RefSeqs XP_004874287 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB18327 (Get FASTA)   NCBI Sequence Viewer  
  JAN98802 (Get FASTA)   NCBI Sequence Viewer  


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002594 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSHGLP00000003515 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000003570 ENTREZGENE, UniProtKB/TrEMBL
InterPro Oxoglu/Fe-dep_dioxygenase UniProtKB/TrEMBL
  Pro_4_hyd_alph UniProtKB/TrEMBL
NCBI Gene Egln2 ENTREZGENE
Pfam 2OG-FeII_Oxy_3 UniProtKB/TrEMBL
PROSITE FE2OG_OXY UniProtKB/TrEMBL
SMART P4Hc UniProtKB/TrEMBL
UniProt G5C9W6 ENTREZGENE, UniProtKB/TrEMBL

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.