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Gene: Acat1 (acetyl-CoA acetyltransferase 1) Rattus norvegicus
Symbol: Acat1
Name: acetyl-CoA acetyltransferase 1
Description: Exhibits several functions, including acetyl-CoA C-acetyltransferase activity; coenzyme binding activity; and identical protein binding activity. Involved in several processes, including animal organ development; response to hormone; and response to starvation. Localizes to mitochondrial matrix. Biomarker of end stage renal disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-schisandrin B; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acetoacetyl-CoA thiolase; Acetyl-Co A acetyltransferase 1 mitochondrial; Acetyl-Co A acetyltransferase 1, mitochondrial; acetyl-CoA acetyltransferase, mitochondrial; acetyl-Coenzyme A acetyltransferase 1; RATACAL
Homo sapiens (human) : ACAT1 (acetyl-CoA acetyltransferase 1)  HGNC  Alliance
Mus musculus (house mouse) : Acat1 (acetyl-Coenzyme A acetyltransferase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acat1 (acetyl-CoA acetyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ACAT1 (acetyl-CoA acetyltransferase 1)
Canis lupus familiaris (dog) : ACAT1 (acetyl-CoA acetyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acat1 (acetyl-CoA acetyltransferase 1)
Sus scrofa (pig) : ACAT1 (acetyl-CoA acetyltransferase 1)
Chlorocebus sabaeus (African green monkey) : ACAT1 (acetyl-CoA acetyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Acat1 (acetyl-CoA acetyltransferase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0858,166,990 - 58,195,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,166,990 - 58,195,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,749,861 - 56,778,336 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4857,044,478 - 57,072,970 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1857,063,521 - 57,092,024 (-)NCBI
Celera853,470,530 - 53,499,505 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Acat1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2016
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.