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Gene: Adcy6 (adenylate cyclase 6) Rattus norvegicus
Symbol: Adcy6
Name: adenylate cyclase 6
CRRD ID: 2035
Description: Exhibits several functions, including SNARE binding activity; calcium- and calmodulin-responsive adenylate cyclase activity; and protein kinase binding activity. Involved in several processes, including cAMP biosynthetic process; maintenance of protein location in plasma membrane; and negative regulation of neuron projection development. Localizes to endosome; membrane raft; and microvillus membrane. Colocalizes with sarcolemma. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADCY6 (adenylate cyclase 6); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; protein kinase A (PKA) signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AC6; ACVI; ADCYB; adenylate cyclase type 6; adenylate cyclase type VI; adenylyl cyclase 6; ATP pyrophosphate-lyase 6; ca(2+)-inhibitable adenylyl cyclase
Homo sapiens (human) : ADCY6 (adenylate cyclase 6)  HGNC  Alliance
Mus musculus (house mouse) : Adcy6 (adenylate cyclase 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adcy6 (adenylate cyclase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : ADCY6 (adenylate cyclase 6)
Canis lupus familiaris (dog) : ADCY6 (adenylate cyclase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adcy6 (adenylate cyclase 6)
Sus scrofa (pig) : ADCY6 (adenylate cyclase 6)
Chlorocebus sabaeus (African green monkey) : ADCY6 (adenylate cyclase 6)
Heterocephalus glaber (naked mole-rat) : Adcy6 (adenylate cyclase 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07140,270,678 - 140,291,722 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,270,692 - 140,291,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,774,376 - 114,795,062 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,339,933 - 137,360,020 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17137,418,113 - 137,437,246 (-)NCBI
Celera7126,233,455 - 126,254,162 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Adcy6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2035
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.