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Gene: Adora1 (adenosine A1 receptor) Rattus norvegicus
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Symbol: Adora1
Name: adenosine A1 receptor
Description: Exhibits several functions, including G protein-coupled adenosine receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of protein modification process; and regulation of secretion. Localizes to several cellular components, including axon; basolateral plasma membrane; and integral component of synaptic membrane. Used to study cerebral infarction; hypertension; lung disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor); INTERACTS WITH (+)-pilocarpine; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adenosine receptor A1
Orthologs:
Homo sapiens (human) : ADORA1 (adenosine A1 receptor)  HGNC  Alliance
Mus musculus (house mouse) : Adora1 (adenosine A1 receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adora1 (adenosine A1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : ADORA1 (adenosine A1 receptor)
Canis lupus familiaris (dog) : ADORA1 (adenosine A1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adora1 (adenosine A1 receptor)
Sus scrofa (pig) : ADORA1 (adenosine A1 receptor)
Chlorocebus sabaeus (African green monkey) : ADORA1 (adenosine A1 receptor)
Heterocephalus glaber (naked mole-rat) : Adora1 (adenosine A1 receptor)
more info ...
Allele / Splice: Adora1em3Mcwi   Adora1em4Mcwi  
Genetic Models: SS-Adora1em4Mcwi SS-Adora1em3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01351,042,111 - 51,076,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,042,248 - 51,076,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,097,883 - 56,132,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,160,292 - 47,192,804 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11347,173,084 - 47,207,198 (-)NCBI
Celera1345,990,556 - 46,022,753 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Adora1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2048
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.