Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Adra2a (adrenoceptor alpha 2A) Rattus norvegicus
Symbol: Adra2a
Name: adrenoceptor alpha 2A
Description: Exhibits alpha2-adrenergic receptor activity. Involved in several processes, including glucose homeostasis; negative regulation of secretion by cell; and negative regulation of uterine smooth muscle contraction. Localizes to several cellular components, including GABA-ergic synapse; glutamatergic synapse; and integral component of synaptic membrane. Used to study anxiety disorder and mental depression. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A); INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Adrenergic alpha 2A receptor; adrenergic receptor, alpha 2a; Adrenergic, alpha 2A, receptor; adrenergic, alpha-2A-, receptor; alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha-2D adrenergic receptor; CA2-47; RATRG20; RG20
Homo sapiens (human) : ADRA2A (adrenoceptor alpha 2A)  HGNC  Alliance
Mus musculus (house mouse) : Adra2a (adrenergic receptor, alpha 2a)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adra2a (adrenoceptor alpha 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRA2A (adrenoceptor alpha 2A)
Canis lupus familiaris (dog) : ADRA2A (adrenoceptor alpha 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adra2a (adrenoceptor alpha 2A)
Sus scrofa (pig) : ADRA2A (adrenoceptor alpha 2A)
Chlorocebus sabaeus (African green monkey) : ADRA2A (adrenoceptor alpha 2A)
Heterocephalus glaber (naked mole-rat) : Adra2a (adrenoceptor alpha 2A)
more info ...
Allele / Splice: Adra2aem1Mcwi  
Genetic Models: SS-Adra2aem1Mcwi-/- SS-Adra2aem1Mcwi
Is Marker For: Strains:   F344.GK-(D1Swe8-D1Gpam-1)/Swe  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01274,766,283 - 274,769,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,766,283 - 274,769,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01282,178,475 - 282,181,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1248,775,483 - 248,778,283 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Adra2a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2056
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.