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Gene: Grk2 (G protein-coupled receptor kinase 2) Rattus norvegicus
Symbol: Grk2
Name: G protein-coupled receptor kinase 2
Description: Exhibits several functions, including opioid receptor binding activity; protein kinase activity; and scaffold protein binding activity. Involved in several processes, including negative regulation of G protein-coupled receptor signaling pathway; negative regulation of cellular protein metabolic process; and positive regulation of nervous system process. Localizes to several cellular components, including basolateral plasma membrane; caveola; and dendrite. Used to study hyperglycemia; impotence; and limb ischemia. Biomarker of Parkinson's disease; congestive heart failure; hypertension; and portal hypertension. Orthologous to human GRK2 (G protein-coupled receptor kinase 2); PARTICIPATES IN dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway; somatostatin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
Also known as: Adrbk1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK1; beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-adrenergic receptor kinase 1, beta ARK1; beta-ARK-1; G-protein-coupled receptor kinase 2; G-protein-linked receptor kinase (beta adrenergic receptor kinase 1); GRK-2
Homo sapiens (human) : GRK2 (G protein-coupled receptor kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Grk2 (G protein-coupled receptor kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk2 (G protein-coupled receptor kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK2 (G protein-coupled receptor kinase 2)
Canis lupus familiaris (dog) : GRK2 (G protein-coupled receptor kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk2 (G protein-coupled receptor kinase 2)
Sus scrofa (pig) : GRK2 (G protein-coupled receptor kinase 2)
Chlorocebus sabaeus (African green monkey) : GRK2 (G protein-coupled receptor kinase 2)
Heterocephalus glaber (naked mole-rat) : Grk2 (G protein-coupled receptor kinase 2)
more info ...
Is Marker For: Strains:   SHHF  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01219,536,220 - 219,544,329 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,536,220 - 219,544,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,406,333 - 226,414,442 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,873,002 - 206,892,868 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11207,026,454 - 207,034,564 (-)NCBI
Celera1199,125,797 - 199,145,728 (-)NCBICelera
Cytogenetic Map1q43NCBI
RH 3.4 Map11560.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Grk2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2062
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.