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Gene: Agtr1b (angiotensin II receptor, type 1b) Rattus norvegicus
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Symbol: Agtr1b
Name: angiotensin II receptor, type 1b
Description: Predicted to have angiotensin type I receptor activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of branching involved in ureteric bud morphogenesis; and response to estrogen. Predicted to localize to the plasma membrane. Biomarker of hypertension and renovascular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); cerebrovascular disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1); PARTICIPATES IN angiotensin III signaling pathway via AT1 receptor; angiotensin II signaling pathway; angiotensin II signaling pathway via AT1 receptor; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Agtr1; Angiotensin II receptor, type 1 (AT1B); angiotensin II receptor, type-1; angiotensin II type-1 receptor; angiotensin II type-1B receptor; angiotensin receptor 1; angiotensin receptor 1b; AT1; At1b; AT3; AT1R; type-1B angiotensin II receptor
Orthologs:
Allele / Splice: Agtr1bm1Mcwi  
Genetic Models: FHH-Agtr1bm1Mcwi
Is Marker For: Strains:   SHR   SD-Tg(Ren2)27   SS.MNS-(D2Mit6-Adh1)/Ayd  
QTLs:   Bp36   Bp99  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02105,149,020 - 105,224,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02124,879,262 - 124,954,378 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42105,503,269 - 105,602,591 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12105,448,230 - 105,547,520 (-)NCBI
Celera298,214,526 - 98,286,355 (-)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Protein Structures
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Agtr1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2071
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.