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Gene: Alas2 (5'-aminolevulinate synthase 2) Rattus norvegicus
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Symbol: Alas2
Name: 5'-aminolevulinate synthase 2
Description: Exhibits 5-aminolevulinate synthase activity; coenzyme binding activity; and glycine binding activity. Involved in several processes, including gland development; response to benzene; and response to lead ion. Localizes to mitochondrion. Biomarker of anemia; bilirubin metabolic disorder; and hemolytic anemia. Human ortholog(s) of this gene implicated in cutaneous porphyria; erythropoietic protoporphyria; hemochromatosis; sideroblastic anemia; and sideroblastic anemia 1. Orthologous to human ALAS2 (5'-aminolevulinate synthase 2); PARTICIPATES IN heme biosynthetic pathway; glycine, serine and threonine metabolic pathway; porphyrin and chlorophyll metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5-aminolevulinic acid synthase 2; ALAS-E; Aminolevulinate synthase 2 delta; Aminolevulinate synthase 2, delta; aminolevulinate, delta-, synthase 2; aminolevulinic acid synthase 2; aminolevulinic acid synthase 2, erythroid; aminolevulinic acid synthase 2, erythroid-like; delta-ALA synthase 2; delta-ALA synthetase; delta-aminolevulinate synthase 2; erythroid-specific delta-aminolevulinate synthase ALAS-E; erythroid-specific delta-aminolevulinate synthase, ALAS-E; LOC100363476
Orthologs:
Homo sapiens (human) : ALAS2 (5'-aminolevulinate synthase 2)  HGNC  Alliance
Mus musculus (house mouse) : Alas2 (aminolevulinic acid synthase 2, erythroid)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alas2 (5'-aminolevulinate synthase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ALAS2 (5'-aminolevulinate synthase 2)
Canis lupus familiaris (dog) : ALAS2 (5'-aminolevulinate synthase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alas2 (5'-aminolevulinate synthase 2)
Sus scrofa (pig) : ALAS2 (5'-aminolevulinate synthase 2)
Chlorocebus sabaeus (African green monkey) : ALAS2 (5'-aminolevulinate synthase 2)
Heterocephalus glaber (naked mole-rat) : Alas2 (5'-aminolevulinate synthase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X23,167,576 - 23,187,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX23,167,696 - 23,187,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X23,587,683 - 23,605,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1X39,853,992 - 39,864,053 (+)NCBI
CeleraX19,742,070 - 19,760,615 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Alas2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2084
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.