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Gene: Aldob (aldolase, fructose-bisphosphate B) Rattus norvegicus
Symbol: Aldob
Name: aldolase, fructose-bisphosphate B
CRRD ID: 2090
Description: Exhibits fructose-bisphosphate aldolase activity and phosphatidylcholine binding activity. Involved in several processes, including response to copper ion; response to fructose; and response to interleukin-6. Localizes to several cellular components, including endoplasmic reticulum membrane; lysosome; and perinuclear region of cytoplasm. Used to study type 2 diabetes mellitus. Biomarker of liver benign neoplasm; peritonitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hereditary fructose intolerance syndrome and type 2 diabetes mellitus. Orthologous to human ALDOB (aldolase, fructose-bisphosphate B); PARTICIPATES IN glycolysis pathway; forkhead class A signaling pathway; fructose and mannose metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: Aldo2; aldolase B; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphate; fructose-bisphosphate aldolase B; LIV10; liver-type aldolase
Homo sapiens (human) : ALDOB (aldolase, fructose-bisphosphate B)  HGNC  Alliance
Mus musculus (house mouse) : Aldob (aldolase B, fructose-bisphosphate)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldob (aldolase, fructose-bisphosphate B)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDOB (aldolase, fructose-bisphosphate B)
Canis lupus familiaris (dog) : ALDOB (aldolase, fructose-bisphosphate B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aldob (aldolase, fructose-bisphosphate B)
Sus scrofa (pig) : ALDOB (aldolase, fructose-bisphosphate B)
Chlorocebus sabaeus (African green monkey) : ALDOB (aldolase, fructose-bisphosphate B)
Heterocephalus glaber (naked mole-rat) : Aldob (aldolase, fructose-bisphosphate B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0564,805,772 - 64,818,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,805,773 - 64,818,824 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0569,297,185 - 69,312,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4566,283,165 - 66,296,171 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1566,288,278 - 66,301,295 (-)NCBI
Celera563,706,063 - 63,718,940 (+)NCBICelera
Cytogenetic Map5q22NCBI
RH 3.4 Map5428.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Aldob
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2090
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.