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Gene: Alox5ap (arachidonate 5-lipoxygenase activating protein) Rattus norvegicus
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Symbol: Alox5ap
Name: arachidonate 5-lipoxygenase activating protein
Description: Exhibits enzyme binding activity; protein heterodimerization activity; and protein homodimerization activity. Contributes to arachidonate 5-lipoxygenase activity. Involved in icosanoid metabolic process; positive regulation of acute inflammatory response; and protein homotrimerization. Localizes to the cytosol; endoplasmic reticulum; and nuclear envelope. Used to study pulmonary hypertension. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including asthma; brain infarction (multiple); breast cancer; cerebral palsy; and coronary artery disease (multiple). Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein); PARTICIPATES IN leukotriene metabolic pathway; lipoxygenase mediated pathway of arachidonic acid metabolism; INTERACTS WITH (RS)-amphetamine; 17alpha-ethynylestradiol; 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5-lipoxygenase-activating protein FLAP; 5-lipoxygenase-activating protein, FLAP; arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0126,854,930 - 6,879,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0128,950,727 - 8,974,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4126,245,808 - 6,269,796 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1126,245,808 - 6,269,796 (-)NCBI
Celera127,507,392 - 7,531,448 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Alox5ap
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2097
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.