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Gene: Alpl (alkaline phosphatase, biomineralization associated) Rattus norvegicus
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Symbol: Alpl
Name: alkaline phosphatase, biomineralization associated
Description: Exhibits alkaline phosphatase activity. Involved in several processes, including cementum mineralization; response to glucocorticoid; and response to lipopolysaccharide. Localizes to extracellular space and plasma membrane. Biomarker of uremia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and uremia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; folate metabolic pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Akp2; alkaline phosphatase 2 liver; alkaline phosphatase 2, liver; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific; alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; MGC93545; PHOA; tissue-nonspecific alkaline phosphatase; tissue-nonspecific ALP alkaline phosphatase; TNSALP
Orthologs:
Homo sapiens (human) : ALPL (alkaline phosphatase, biomineralization associated)  HGNC  Alliance
Mus musculus (house mouse) : Alpl (alkaline phosphatase, liver/bone/kidney)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alpl (alkaline phosphatase, biomineralization associated)
Pan paniscus (bonobo/pygmy chimpanzee) : ALPL (alkaline phosphatase, biomineralization associated)
Canis lupus familiaris (dog) : ALPL (alkaline phosphatase, biomineralization associated)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alpl (alkaline phosphatase, biomineralization associated)
Sus scrofa (pig) : ALPL (alkaline phosphatase, biomineralization associated)
Chlorocebus sabaeus (African green monkey) : ALPL (alkaline phosphatase, biomineralization associated)
Heterocephalus glaber (naked mole-rat) : Alpl (alkaline phosphatase, biomineralization associated)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05156,086,496 - 156,141,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,841,916 - 159,897,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,501,739 - 156,558,727 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,511,778 - 156,568,766 (-)NCBI
Celera5148,347,371 - 148,402,292 (-)NCBICelera
Cytogenetic Map5q36NCBI
RH 3.4 Map51009.6RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Alpl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2100
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.