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Gene: Leprem4Lizh (leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh) Rattus norvegicus
Symbol: Leprem4Lizh
Name: leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh
Description: The Lepr knockout mutation were generated by CRISPR/Cas9. The resulting mutaion is a 298-bp deletion from No. 90043 bp to 90341 bp in the Lepr genome DNA sequence (NC_005104.4) and a 4-bp insertion and resulted in a termination codon TGA. For genotyping, a 662-bp fragment of WT and a 368-bp fragment of the Lepr knockout gene were amplified with PCR.
ASSOCIATED WITH decreased bone mineral density; decreased trabecular bone volume; expanded mesangial matrix; ASSOCIATED WITH Dyslipidemias; glucose intolerance; hyperglycemia
Type: allele  of Lepr  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position: No map positions available.

References - curated




Nucleotide Sequences

Additional Information

More on Leprem4Lizh
Alliance Gene
Ensembl Gene
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 21079476
Created: 2020-02-18
Species: Rattus norvegicus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.