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Gene: Apoc3 (apolipoprotein C3) Rattus norvegicus
Symbol: Apoc3
Name: apolipoprotein C3
CRRD ID: 2136
Description: Predicted to have high-density lipoprotein particle receptor binding activity; lipase inhibitor activity; and phospholipid binding activity. Involved in several processes, including cellular response to glucose stimulus; lipoprotein transport; and positive regulation of triglyceride biosynthetic process. Localizes to extracellular space. Used to study hyperthyroidism; hypothyroidism; and type 1 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in several diseases, including apolipoprotein C-III deficiency; chronic kidney disease; coronary artery disease; familial hyperlipidemia (multiple); and glucose metabolism disease (multiple). Orthologous to human APOC3 (apolipoprotein C3); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-schisandrin B; 1-nitropropane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apo-CIII; ApoC-III; apolipoprotein C-3; apolipoprotein C-III
Homo sapiens (human) : APOC3 (apolipoprotein C3)  HGNC  Alliance
Mus musculus (house mouse) : Apoc3 (apolipoprotein C-III)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoc3 (apolipoprotein C3)
Pan paniscus (bonobo/pygmy chimpanzee) : APOC3 (apolipoprotein C3)
Canis lupus familiaris (dog) : APOC3 (apolipoprotein C3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoc3 (apolipoprotein C3)
Sus scrofa (pig) : APOC3 (apolipoprotein C3)
Chlorocebus sabaeus (African green monkey) : APOC3 (apolipoprotein C3)
Heterocephalus glaber (naked mole-rat) : Apoc3 (apolipoprotein C3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0850,529,318 - 50,531,498 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,529,318 - 50,531,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,155,390 - 49,157,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.18159,618,812 - 159,618,833NCBI
Celera846,113,508 - 46,115,688 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Apoc3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2136
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.