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Gene: Apoe (apolipoprotein E) Rattus norvegicus
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Symbol: Apoe
Name: apolipoprotein E
Description: Exhibits several functions, including amyloid-beta binding activity; hydroxyapatite binding activity; and phospholipid binding activity. Involved in several processes, including cellular response to alcohol; neurogenesis; and regulation of lipid metabolic process. Localizes to several cellular components, including discoidal high-density lipoprotein particle; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Colocalizes with early endosome and microtubule. Used to study artery disease (multiple); familial hyperlipidemia; fatty liver disease (multiple); glomerulosclerosis; and middle cerebral artery infarction. Biomarker of several diseases, including glomerulonephritis (multiple); hyperhomocysteinemia; hypothyroidism; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apo-E; APOEA
Orthologs:
Homo sapiens (human) : APOE (apolipoprotein E)  HGNC  Alliance
Mus musculus (house mouse) : Apoe (apolipoprotein E)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoe (apolipoprotein E)
Pan paniscus (bonobo/pygmy chimpanzee) : APOE (apolipoprotein E)
Canis lupus familiaris (dog) : APOE (apolipoprotein E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoe (apolipoprotein E)
Sus scrofa (pig) : APOE (apolipoprotein E)
Chlorocebus sabaeus (African green monkey) : APOE (apolipoprotein E)
Heterocephalus glaber (naked mole-rat) : Apoe (apolipoprotein E)
more info ...
Allele / Splice: Apoeem8Mcwi   Apoeem7Mcwi   Apoeem9Mcwi   Apoeem1Sage  
Genetic Models: SD-Apoeem1Sage SS-Apoeem9Mcwi SS-Apoeem8Mcwi SS-Apoeem7Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0180,612,894 - 80,616,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,612,895 - 80,617,057 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,878,372 - 81,882,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,003,634 - 79,006,387 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1179,081,854 - 79,083,684 (-)NCBI
Celera173,813,122 - 73,817,046 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Apoe
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2138
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.