Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Aqp2 (aquaporin 2) Rattus norvegicus
Analyze
Symbol: Aqp2
Name: aquaporin 2
Description: Exhibits PDZ domain binding activity; actin binding activity; and water transmembrane transporter activity. Involved in several processes, including actin filament depolymerization; cellular response to water deprivation; and response to glucagon. Localizes to several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and trans-Golgi network. Biomarker of hypertension and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus. Orthologous to human AQP2 (aquaporin 2); PARTICIPATES IN vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; amiloride pharmacodynamics pathway; INTERACTS WITH (R)-noradrenaline; 17beta-estradiol; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ADH water channel; AQP-2; AQP-CD; aquaporin 2 (collecting duct); aquaporin-2; aquaporin-CD; collecting duct water channel protein; MGC156502; water channel protein for renal collecting duct; WCH-CD
Orthologs:
Homo sapiens (human) : AQP2 (aquaporin 2)  HGNC  Alliance
Mus musculus (house mouse) : Aqp2 (aquaporin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aqp2 (aquaporin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AQP2 (aquaporin 2)
Canis lupus familiaris (dog) : AQP2 (aquaporin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aqp2 (aquaporin 2)
Sus scrofa (pig) : AQP2 (aquaporin 2)
Chlorocebus sabaeus (African green monkey) : AQP2 (aquaporin 2)
Heterocephalus glaber (naked mole-rat) : Aqp2 (aquaporin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07141,237,802 - 141,242,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,237,768 - 141,245,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,742,312 - 115,747,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,325,855 - 138,330,891 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17138,402,285 - 138,406,831 (+)NCBI
Celera7127,193,026 - 127,197,996 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Aqp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2142
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.