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Gene: Aqp4 (aquaporin 4) Rattus norvegicus
Symbol: Aqp4
Name: aquaporin 4
Description: Exhibits identical protein binding activity and water channel activity. Involved in several processes, including cellular chemical homeostasis; cellular response to cytokine stimulus; and regulation of cytokine production. Localizes to several cellular components, including T-tubule; astrocyte end-foot; and basal plasma membrane. Used to study diabetic retinopathy and status epilepticus. Biomarker of several diseases, including brain edema; cerebrovascular disease (multiple); eye disease (multiple); hydrocephalus; and primary biliary cirrhosis. Human ortholog(s) of this gene implicated in Meniere's disease; blindness; neuromyelitis optica; optic neuritis; and temporal lobe epilepsy. Orthologous to human AQP4 (aquaporin 4); PARTICIPATES IN water transport pathway; bile acid transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (+)-pilocarpine; 1,2-dichloroethane; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AQP-4; AQP4.M23; aquaporin 4.M23; aquaporin-4; mercurial-insensitive water channel; Miwc; MIWC2; WCH4
Homo sapiens (human) : AQP4 (aquaporin 4)  HGNC  Alliance
Mus musculus (house mouse) : Aqp4 (aquaporin 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aqp4 (aquaporin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : AQP4 (aquaporin 4)
Canis lupus familiaris (dog) : AQP4 (aquaporin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aqp4 (aquaporin 4)
Sus scrofa (pig) : AQP4 (aquaporin 4)
Chlorocebus sabaeus (African green monkey) : AQP4 (aquaporin 4)
Heterocephalus glaber (naked mole-rat) : Aqp4 (aquaporin 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
Cytogenetic Map18p13NCBI
RH 3.4 Map1886.21RGD
RH 3.4 Map1878.3RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Aqp4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2143
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.