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Gene: Arg1 (arginase 1) Rattus norvegicus
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Symbol: Arg1
Name: arginase 1
Description: Exhibits arginase activity and manganese ion binding activity. Involved in several processes, including cellular response to lipid; gland development; and response to vitamin. Localizes to several cellular components, including the extracellular space; mitochondrial outer membrane; and neuronal cell body. Used to study hypertension. Biomarker of several diseases, including acute kidney failure; cholestasis; silicosis; ureteral obstruction; and uveitis. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1); PARTICIPATES IN urea cycle pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-bromopropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI type I arginase; AI, type I arginase; arginase 1 liver; Arginase 1, liver; arginase, liver; arginase-1; liver-type arginase; type I arginase
Orthologs:
Homo sapiens (human) : ARG1 (arginase 1)  HGNC  Alliance
Mus musculus (house mouse) : Arg1 (arginase, liver)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arg1 (arginase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ARG1 (arginase 1)
Canis lupus familiaris (dog) : ARG1 (arginase 1)
Sus scrofa (pig) : ARG1 (arginase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0121,525,421 - 21,537,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0123,005,260 - 23,017,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4120,998,894 - 21,011,275 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1120,999,006 - 21,011,333 (+)NCBI
Celera119,228,309 - 19,241,078 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Arg1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2150
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.