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Gene: Arg2 (arginase 2) Rattus norvegicus
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Symbol: Arg2
Name: arginase 2
Description: Exhibits arginase activity and nitric-oxide synthase binding activity. Involved in several processes, including arginine catabolic process to ornithine; cellular response to cytokine stimulus; and cellular response to lipid. Localizes to the mitochondrion. Used to study hypertension. Biomarker of acute kidney failure; end stage renal failure; hypertension; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (arginase 2); PARTICIPATES IN urea cycle pathway; arginine and proline metabolic pathway; Entamoebiasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AII type II arginase; AII, type II arginase; arginase II; arginase type II; arginase-2, mitochondrial; kidney-type arginase; non-hepatic arginase; type II arginase
Orthologs:
Homo sapiens (human) : ARG2 (arginase 2)  HGNC  Alliance
Mus musculus (house mouse) : Arg2 (arginase type II)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arg2 (arginase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ARG2 (arginase 2)
Canis lupus familiaris (dog) : ARG2 (arginase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arg2 (arginase 2)
Sus scrofa (pig) : ARG2 (arginase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06102,311,097 - 102,338,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06114,998,810 - 115,025,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,901,653 - 101,928,282 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16101,905,108 - 101,931,737 (+)NCBI
Celera696,321,210 - 96,346,531 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Arg2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2151
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.