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Gene: Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2) Rattus norvegicus
Symbol: Atp1a2
Name: ATPase Na+/K+ transporting subunit alpha 2
CRRD ID: 2168
Description: Exhibits several functions, including ATP binding activity; protein heterodimerization activity; and sodium:potassium-exchanging ATPase activity. Predicted to contribute to ATPase activity; alkali metal ion binding activity; and drug binding activity. Involved in several processes, including cellular response to mechanical stimulus; monovalent inorganic cation transport; and negative regulation of calcium:sodium antiporter activity. Localizes to several cellular components, including T-tubule; intercalated disc; and sodium:potassium-exchanging ATPase complex. Biomarker of hyperhomocysteinemia and hypertension. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPase Na+K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; ATPase, Na+K+ transporting, alpha 2 polypeptide; na(+)/K(+) ATPase alpha(+) subunit; na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; RATATPA2; sodium pump subunit alpha-2; sodium/potassium-transporting ATPase subunit alpha-2
Homo sapiens (human) : ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2)  HGNC  Alliance
Mus musculus (house mouse) : Atp1a2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101966570 (sodium/potassium-transporting ATPase subunit alpha-2)
Sus scrofa (pig) : ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2)
Chlorocebus sabaeus (African green monkey) : ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2)
more info ...
Is Marker For: QTLs:   Bp80  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01390,651,682 - 90,676,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,651,686 - 90,676,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,173,343 - 95,198,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,258,993 - 88,283,918 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11388,447,876 - 88,472,802 (-)NCBI
Celera1384,339,662 - 84,364,561 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Atp1a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2168
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.