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Gene: Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2) Rattus norvegicus
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Symbol: Atp1a2
Name: ATPase Na+/K+ transporting subunit alpha 2
Description: Exhibits ATP binding activity; sodium:potassium-exchanging ATPase activity; and steroid hormone binding activity. Predicted to contribute to ATPase activity; alkali metal ion binding activity; and drug binding activity. Involved in several processes, including cellular response to mechanical stimulus; monovalent inorganic cation transport; and negative regulation of calcium:sodium antiporter activity. Localizes to several cellular components, including the T-tubule; endosome; and sodium:potassium-exchanging ATPase complex. Biomarker of hyperhomocysteinemia and hypertension. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPase Na+K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; ATPase, Na+K+ transporting, alpha 2 polypeptide; na(+)/K(+) ATPase alpha(+) subunit; na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; RATATPA2; sodium pump subunit alpha-2; sodium/potassium-transporting ATPase subunit alpha-2
Orthologs:
Is Marker For: QTLs:   Bp80  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01390,651,682 - 90,676,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01395,173,343 - 95,198,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,258,993 - 88,283,918 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11388,447,876 - 88,472,802 (-)NCBI
Celera1384,339,662 - 84,364,561 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Atp1a2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2168
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.