Gene: Atp2a2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) Rattus norvegicus
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Symbol: Atp2a2
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Description: Exhibits several functions, including ATP binding activity, calcium ion binding activity, and calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential; involved in several processes, including cation transport, cellular response to heat, and regulation of cardiac muscle contraction; localizes to several cellular components, including the apical ectoplasmic specialization, cytoplasm, and extrinsic component of cytoplasmic side of plasma membrane; predicted to colocalize with the intercalated disc; used to study abdominal obesity-metabolic syndrome 1, congestive heart failure, and type 2 diabetes mellitus; biomarker of euthyroid sick syndrome, heart disease, hypothyroidism, pulmonary hypertension, and type 2 diabetes mellitus; orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; Serca2; SercaII; SR Ca(2+)-ATPase 2
Orthologs:
Is Marker For: QTLs:   Calcic1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01239,553,903 - 39,603,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01241,434,651 - 41,482,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,266,600 - 35,316,237 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,129,987 - 35,179,584 (+)NCBI
Celera1235,744,606 - 35,793,364 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Atp2a2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2174
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.