Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Atp7b (ATPase copper transporting beta) Rattus norvegicus
Analyze
Symbol: Atp7b
Name: ATPase copper transporting beta
Description: Exhibits copper ion binding activity; copper ion transmembrane transporter activity; and zinc ion binding activity. Involved in several processes, including cellular response to metal ion; copper ion export; and lactation. Localizes to several cellular components, including the basolateral plasma membrane; bicellular tight junction; and trans-Golgi network. Predicted to colocalize with the cytoplasmic vesicle. Used to study Wilson disease. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta); PARTICIPATES IN cisplatin drug pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPase Cu++ transporting beta polypeptide (same as Wilson disease); ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease); copper pump 2; copper-transporting ATPase 2; Hts; PINA; PINA gene, promoter; pineal night-specific ATPase; Wd; wilson disease-associated protein homolog
Orthologs:
Homo sapiens (human) : ATP7B (ATPase copper transporting beta)  HGNC  Alliance
Mus musculus (house mouse) : Atp7b (ATPase, Cu++ transporting, beta polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp7b (ATPase copper transporting beta)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP7B (ATPase copper transporting beta)
Canis lupus familiaris (dog) : ATP7B (ATPase copper transporting beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp7b (ATPase copper transporting beta)
Sus scrofa (pig) : ATP7B (ATPase copper transporting beta)
more info ...
Allele / Splice: Atp7bhts  
Genetic Models: LEC/Hok
Is Marker For: Strains:   LEC/Tj   WKAH.LEC-Atp7bhts/Tj  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01674,865,516 - 74,944,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01674,495,179 - 74,575,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,607,988 - 74,680,080 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11674,608,239 - 74,679,614 (+)NCBI
Celera1667,837,288 - 67,908,140 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
RH 3.4 Map16664.21RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Atp7b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2180
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.