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Gene: Bax (BCL2 associated X, apoptosis regulator) Rattus norvegicus
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Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Description: Exhibits BH domain binding activity; chaperone binding activity; and heat shock protein binding activity. Involved in several processes, including mitochondrial membrane organization; release of cytochrome c from mitochondria; and response to corticosterone. Localizes to cytosol; mitochondrial outer membrane; and perinuclear region of cytoplasm. Predicted to colocalize with cell periphery. Used to study brain glioma; endometriosis; morphine dependence; and pre-malignant neoplasm. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain disease (multiple); heart disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator); PARTICIPATES IN intrinsic apoptotic pathway; ceramide signaling pathway; syndecan signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-catechin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apoptosis regulator BAX; Bcl2-associated X protein
Orthologs:
Homo sapiens (human) : BAX (BCL2 associated X, apoptosis regulator)  HGNC  Alliance
Mus musculus (house mouse) : Bax (BCL2-associated X protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bax (BCL2 associated X, apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : BAX (BCL2 associated X, apoptosis regulator)
Canis lupus familiaris (dog) : BAX (BCL2 associated X, apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bax (BCL2 associated X, apoptosis regulator)
Sus scrofa (pig) : BAX (BCL2 associated X, apoptosis regulator)
Chlorocebus sabaeus (African green monkey) : BAX (BCL2 associated X, apoptosis regulator)
Heterocephalus glaber (naked mole-rat) : Bax (BCL2 associated X, apoptosis regulator)
more info ...
Allele / Splice: Bax_v1   Bax_v2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01101,451,801 - 101,457,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,451,802 - 101,457,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,530,747 - 102,536,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,933,023 - 95,938,176 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,011,133 - 96,016,287 (-)NCBI
Celera190,195,913 - 90,201,319 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model