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Gene: Bdkrb2 (bradykinin receptor B2) Rattus norvegicus
Symbol: Bdkrb2
Name: bradykinin receptor B2
Description: Exhibits beta-2 adrenergic receptor binding activity and bradykinin receptor activity. Involved in several processes, including acute inflammatory response to antigenic stimulus; cellular response to hypoxia; and maintenance of blood-brain barrier. Localizes to plasma membrane. Used to study several diseases, including diabetic retinopathy; pancreatitis; pleurisy; portal hypertension; and pulmonary hypertension. Biomarker of hypertension; malignant glioma; myocardial infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; diabetic retinopathy; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; kallikrein-kinin cascade pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic GMP; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B2 bradykinin receptor; B2BKR; B2BRA; B2R; BK-2 receptor; bradykinin receptor, beta 2
Homo sapiens (human) : BDKRB2 (bradykinin receptor B2)  HGNC  Alliance
Mus musculus (house mouse) : Bdkrb2 (bradykinin receptor, beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bdkrb2 (bradykinin receptor B2)
Pan paniscus (bonobo/pygmy chimpanzee) : BDKRB2 (bradykinin receptor B2)
Canis lupus familiaris (dog) : BDKRB2 (bradykinin receptor B2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bdkrb2 (bradykinin receptor B2)
Sus scrofa (pig) : BDKRB2 (bradykinin receptor B2)
Chlorocebus sabaeus (African green monkey) : BDKRB2 (bradykinin receptor B2)
Heterocephalus glaber (naked mole-rat) : Bdkrb2 (bradykinin receptor B2)
more info ...
Allele / Splice: Bdkrb2m1Mcwi   Bdkrb2m2Mcwi  
Genetic Models: FHH-Bdkrb2m1Mcwi SS-Bdkrb2m2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06129,399,468 - 129,429,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6129,399,468 - 129,429,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06138,615,812 - 138,622,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46129,744,781 - 129,748,851 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16129,748,527 - 129,752,598 (+)NCBI
Celera6122,039,524 - 122,069,422 (+)NCBICelera
Cytogenetic Map6q32NCBI
RH 3.4 Map6815.41RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Bdkrb2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2201
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.