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Gene: Bglap (bone gamma-carboxyglutamate protein) Rattus norvegicus
Symbol: Bglap
Name: bone gamma-carboxyglutamate protein
Description: A structural constituent of bone. Involved in several processes, including osteoblast development; response to testosterone; and response to vitamin. Localizes to several cellular components, including Golgi apparatus; perikaryon; and rough endoplasmic reticulum. Used to study congenital hypothyroidism and osteoporosis. Biomarker of autosomal dominant hypocalcemia; end stage renal failure; and polycystic kidney disease. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein); PARTICIPATES IN fibroblast growth factor signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Bglap2; Bgp; BGPR; BGPRA; bone gamma-carboxyglutamate (gla) protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); bone gamma-carboxyglutamate protein 2; bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin); bone Gla protein; bone Gla-protein; gamma-carboxyglutamic acid-containing protein; osteocalcin
Homo sapiens (human) : BGLAP (bone gamma-carboxyglutamate protein)  HGNC  Alliance
Mus musculus (house mouse) : Bglap (bone gamma carboxyglutamate protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bglap (bone gamma-carboxyglutamate protein)
Pan paniscus (bonobo/pygmy chimpanzee) : BGLAP (bone gamma-carboxyglutamate protein)
Canis lupus familiaris (dog) : BGLAP (bone gamma-carboxyglutamate protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bglap (bone gamma-carboxyglutamate protein)
Sus scrofa (pig) : BGLAP (bone gamma-carboxyglutamate protein)
Chlorocebus sabaeus (African green monkey) : BGLAP (bone gamma-carboxyglutamate protein)
Heterocephalus glaber (naked mole-rat) : Bglap (bone gamma-carboxyglutamate protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02187,741,770 - 187,748,445 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,741,770 - 187,742,747 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,144,494 - 207,150,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,482,313 - 180,483,290 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,432,418 - 180,433,396 (-)NCBI
Celera2167,783,260 - 167,784,237 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Bglap
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2206
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.