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Gene: C2 (complement C2) Rattus norvegicus
Symbol: C2
Name: complement C2
Description: Predicted to have serine-type endopeptidase activity. Involved in response to nutrient. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in Alzheimer's disease; age related macular degeneration 14; complement component 2 deficiency; macular degeneration; and psoriasis. Orthologous to human C2 (complement C2); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: complement component 2
Homo sapiens (human) : C2 (complement C2)  HGNC  Alliance
Mus musculus (house mouse) : C2 (complement component 2 (within H-2S))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : C2 (complement C2)
Pan paniscus (bonobo/pygmy chimpanzee) : C2 (complement C2)
Canis lupus familiaris (dog) : C2 (complement C2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : C2 (complement C2)
Sus scrofa (pig) : C2 (complement C2)
Heterocephalus glaber (naked mole-rat) : C2 (complement C2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0204,542,340 - 4,561,152 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,542,340 - 4,561,152 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,622,139 - 6,641,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,051,146 - 4,071,909 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,051,372 - 4,072,135 (+)NCBI
Celera204,060,318 - 4,078,802 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on C2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2231
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.