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Gene: Capn2 (calpain 2) Rattus norvegicus
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Symbol: Capn2
Name: calpain 2
Description: Exhibits several functions, including calcium-dependent cysteine-type endopeptidase activity; cytoskeletal protein binding activity; and enzyme binding activity. Involved in several processes, including cellular response to interferon-beta; positive regulation of cell death; and positive regulation of myoblast fusion. Localizes to several cellular components, including the cytosol; external side of plasma membrane; and focal adhesion. Colocalizes with the mitochondrial intermembrane space. Biomarker of hypertrophic cardiomyopathy and sciatic neuropathy. Orthologous to human CAPN2 (calpain 2); PARTICIPATES IN the proteolytic pathway involving calcium-dependent proteases; Alzheimer's disease pathway; apoptotic cell death pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: calcium-activated neutral proteinase 2; calpain 2, (m/II) large subunit; calpain II; calpain M-type; calpain-2 catalytic subunit; calpain-2 large subunit; CANP 2; M-calpain; millimolar-calpain
Orthologs:
Homo sapiens (human) : CAPN2 (calpain 2)  HGNC  Alliance
Mus musculus (house mouse) : Capn2 (calpain 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Capn2 (calpain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CAPN2 (calpain 2)
Canis lupus familiaris (dog) : CAPN2 (calpain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Capn2 (calpain 2)
Sus scrofa (pig) : CAPN2 (calpain 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.013100,878,649 - 100,928,811 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013105,814,749 - 105,864,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41398,473,367 - 98,524,463 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11398,662,303 - 98,713,399 (-)NCBI
Celera1393,683,410 - 93,734,060 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Capn2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2268
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.