Gene: Casq2 (calsequestrin 2) Rattus norvegicus
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Symbol: Casq2
Name: calsequestrin 2
Description: Exhibits protein homodimerization activity and protein kinase C binding activity; involved in negative regulation of ryanodine-sensitive calcium-release channel activity, regulation of cardiac muscle cell contraction, and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; localizes to the Z disc and sarcoplasmic reticulum; biomarker of congestive heart failure and supravalvular aortic stenosis; orthologous to human CASQ2 (calsequestrin 2); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (RS)-amphetamine; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calsequestrin 2 (cardiac muscle); calsequestrin, cardiac muscle isoform; calsequestrin-2; cardCSQ; SR calcium binding protein
Orthologs:
Homo sapiens (human) : CASQ2 (calsequestrin 2)  HGNC  Alliance
Mus musculus (house mouse) : Casq2 (calsequestrin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casq2 (calsequestrin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CASQ2 (calsequestrin 2)
Canis lupus familiaris (dog) : CASQ2 (calsequestrin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casq2 (calsequestrin 2)
Sus scrofa (pig) : CASQ2 (calsequestrin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02204,512,361 - 204,568,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02223,945,611 - 224,001,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,182,938 - 197,239,201 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12197,145,718 - 197,201,199 (+)NCBI
Celera2181,958,395 - 182,014,660 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Casq2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2276
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.