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Gene: Casr (calcium-sensing receptor) Rattus norvegicus
Symbol: Casr
Name: calcium-sensing receptor
Description: Exhibits integrin binding activity; ion channel binding activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular chemical homeostasis; and regulation of blood vessel diameter. Localizes to several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Used to study cardiomyopathy. Biomarker of atherosclerosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aluminium atom.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); extracellular calcium-sensing receptor; parathyroid Cell calcium-sensing receptor; PCaR1; RaKCaR
Homo sapiens (human) : CASR (calcium sensing receptor)  HGNC  Alliance
Mus musculus (house mouse) : Casr (calcium-sensing receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casr (calcium sensing receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : CASR (calcium sensing receptor)
Canis lupus familiaris (dog) : CASR (calcium sensing receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casr (calcium sensing receptor)
Sus scrofa (pig) : CASR (calcium sensing receptor)
Chlorocebus sabaeus (African green monkey) : CASR (calcium sensing receptor)
Heterocephalus glaber (naked mole-rat) : Casr (calcium sensing receptor)
more info ...
Allele / Splice: Casrem1Mcwi  
Genetic Models: SS-Casrem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01167,188,204 - 67,262,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,188,630 - 67,258,771 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,278,784 - 70,352,137 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,084,169 - 66,153,292 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11166,141,757 - 66,210,881 (-)NCBI
Celera1163,705,377 - 63,774,888 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Casr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2277
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.