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Gene: Cast (calpastatin) Rattus norvegicus
Symbol: Cast
Name: calpastatin
Description: Exhibits calcium-dependent cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ development; myoblast fusion; and negative regulation of cell cycle arrest. Localizes to several cellular components, including cytoplasm; nucleus; and postsynaptic density. Used to study brain ischemia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); congenital myasthenic syndrome 1A; pemphigus; rheumatoid arthritis; and vasculitis. Orthologous to human CAST (calpastatin); PARTICIPATES IN the proteolytic pathway involving calcium-dependent proteases; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calpain inhibitor; Calpastatin (probably multiple splicing products); MGC108997
Homo sapiens (human) : CAST (calpastatin)  HGNC  Alliance
Mus musculus (house mouse) : Cast (calpastatin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cast (calpastatin)
Pan paniscus (bonobo/pygmy chimpanzee) : CAST (calpastatin)
Canis lupus familiaris (dog) : CAST (calpastatin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cast (calpastatin)
Sus scrofa (pig) : CAST (calpastatin)
Chlorocebus sabaeus (African green monkey) : CAST (calpastatin)
Heterocephalus glaber (naked mole-rat) : Cast (calpastatin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.021,452,111 - 1,561,669 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl21,452,116 - 1,561,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.021,422,022 - 1,530,917 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.421,495,048 - 1,608,477 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.121,497,323 - 1,558,604 (-)NCBI
Celera2468,414 - 578,127 (-)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cast
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2278
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.