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Gene: Cav1 (caveolin 1) Rattus norvegicus
Symbol: Cav1
Name: caveolin 1
Description: Exhibits several functions, including enzyme binding activity; ion channel binding activity; and syntaxin binding activity. Involved in several processes, including positive regulation of cellular component organization; regulation of endothelial cell proliferation; and regulation of signal transduction. Localizes to several cellular components, including basal plasma membrane; caveola; and focal adhesion. Predicted to colocalize with sarcolemma. Biomarker of several diseases, including artery disease (multiple); bone disease (multiple); brain ischemia (multiple); obesity; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1); PARTICIPATES IN insulin signaling pathway; platelet-derived growth factor signaling pathway; reverse cholesterol transport pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cav; caveolin; caveolin 1, caveolae protein; Caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; Caveolin, caveolae protein, 22 kDa; caveolin-1; caveolin-like; LOC100362870; MGC187299
Homo sapiens (human) : CAV1 (caveolin 1)  HGNC  Alliance
Mus musculus (house mouse) : Cav1 (caveolin 1, caveolae protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cav1 (caveolin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CAV1 (caveolin 1)
Canis lupus familiaris (dog) : CAV1 (caveolin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cav1 (caveolin 1)
Sus scrofa (pig) : CAV1 (caveolin 1)
Chlorocebus sabaeus (African green monkey) : CAV1 (caveolin 1)
Heterocephalus glaber (naked mole-rat) : Cav1 (caveolin 1)
more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cav1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2280
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.