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Gene: Runx1 (RUNX family transcription factor 1) Rattus norvegicus
Symbol: Runx1
Name: RUNX family transcription factor 1
Description: Exhibits promoter-specific chromatin binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including ovulation; positive regulation of progesterone secretion; and response to denervation involved in regulation of muscle adaptation. Localizes to nucleus. Used to study middle cerebral artery infarction. Biomarker of endometriosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; asthma; hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human RUNX1 (RUNX family transcription factor 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; acute myeloid leukemia pathway; chronic myeloid leukemia pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acute myeloid leukemia 1; Aml1; B; CBF-alpha-2; Cbfa2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); core-binding factor subunit alpha-2; oncogene AML-1; PEA2-alpha; PEA2-alpha B; PEBP2-alpha; PEBP2-alpha B; polyomavirus enhancer-binding protein 2 alpha B subunit; runt related transcription factor 1; runt-related transcription factor 1
Homo sapiens (human) : RUNX1 (RUNX family transcription factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Runx1 (runt related transcription factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Runx1 (RUNX family transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RUNX1 (RUNX family transcription factor 1)
Canis lupus familiaris (dog) : RUNX1 (RUNX family transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Runx1 (RUNX family transcription factor 1)
Sus scrofa (pig) : RUNX1 (RUNX family transcription factor 1)
Chlorocebus sabaeus (African green monkey) : RUNX1 (RUNX family transcription factor 1)
Heterocephalus glaber (naked mole-rat) : Runx1 (RUNX family transcription factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01132,765,147 - 33,003,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,769,165 - 33,003,021 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,367,315 - 36,601,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,623,461 - 32,725,404 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11132,679,703 - 32,781,647 (-)NCBI
Celera1131,494,069 - 31,582,728 (-)NCBICelera
Cytogenetic Map11q11NCBI
RH 3.4 Map11214.7RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Runx1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2283
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.