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Gene: MIR874 (microRNA 874) Homo sapiens
Symbol: MIR874
Name: microRNA 874
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
Also known as: hsa-mir-874; mir-874; MIRN874
Mus musculus (house mouse) : Mir874 (microRNA 874)  MGI
Rattus norvegicus (Norway rat) : Mir874 (microRNA 874)  Alliance
Canis lupus familiaris (dog) : MIR874 (microRNA mir-874)
Sus scrofa (pig) : MIR874 (microRNA mir-874)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5137,647,572 - 137,647,649 (-)Ensembl
GRCh385137,647,572 - 137,647,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375136,983,261 - 136,983,338 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,011,159 - 137,011,236 (-)NCBINCBI36hg18NCBI36
Celera5133,106,035 - 133,106,112 (-)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5132,169,849 - 132,169,926 (-)NCBIHuRef
CHM1_15136,414,189 - 136,414,266 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
More on MIR874
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2290213
Created: 2008-02-29
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.