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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | ISO | RGD:1617458 | 6480464 | vinylidene chloride results in decreased expression of TMEM213 mRNA | CTD | PMID:26682919 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1617458 | 6480464 | Fenretinide results in increased expression of TMEM213 mRNA | CTD | PMID:28973697 | aflatoxin B2 | decreases methylation | EXP | | 6480464 | aflatoxin B2 results in decreased methylation of TMEM213 polyA tail | CTD | PMID:30157460 | benzo[a]pyrene | increases expression | ISO | RGD:1617458 | 6480464 | Benzo(a)pyrene results in increased expression of TMEM213 mRNA | CTD | PMID:21569818 | Benzo[k]fluoranthene | increases expression | ISO | RGD:1617458 | 6480464 | benzo(k)fluoranthene results in increased expression of TMEM213 mRNA | CTD | PMID:26377693 | bisphenol A | affects expression | ISO | RGD:1588740 | 6480464 | bisphenol A affects the expression of TMEM213 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | RGD:1588740 | 6480464 | [bisphenol A co-treated with tributyltin] results in decreased expression of TMEM213 mRNA | CTD | PMID:31129395 | C60 fullerene | decreases expression | ISO | RGD:1588740 | 6480464 | fullerene C60 results in decreased expression of TMEM213 mRNA | CTD | PMID:19167457 | carbon nanotube | increases expression | ISO | RGD:1617458 | 6480464 | Nanotubes, Carbon analog results in increased expression of TMEM213 mRNA, Nanotubes, Carbon results in increased expression of TMEM213 mRNA | CTD | PMID:25554681 | nickel atom | decreases expression | EXP | | 6480464 | Nickel results in decreased expression of TMEM213 mRNA | CTD | PMID:24768652, PMID:25583101 | pioglitazone | multiple interactions | ISO | RGD:1617458 | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of TMEM213 mRNA | CTD | PMID:27935865 | silicon dioxide | decreases expression | EXP | | 6480464 | Silicon Dioxide analog results in decreased expression of TMEM213 mRNA | CTD | PMID:23806026 | titanium dioxide | affects expression | ISO | RGD:1617458 | 6480464 | titanium dioxide affects the expression of TMEM213 mRNA | CTD | PMID:23557971 | titanium dioxide | increases expression | ISO | RGD:1617458 | 6480464 | titanium dioxide results in increased expression of TMEM213 mRNA | CTD | PMID:27760801 | tributylstannane | multiple interactions | ISO | RGD:1588740 | 6480464 | [bisphenol A co-treated with tributyltin] results in decreased expression of TMEM213 mRNA | CTD | PMID:31129395 | zoledronic acid | decreases expression | EXP | | 6480464 | zoledronic acid results in decreased expression of TMEM213 mRNA | CTD | PMID:24714768 | |
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TMEM213 (Homo sapiens - human) |
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Tmem213 (Mus musculus - house mouse) |
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Tmem213 (Rattus norvegicus - Norway rat) |
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Tmem213 (Chinchilla lanigera - long-tailed chinchilla) |
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TMEM213 (Pan paniscus - bonobo/pygmy chimpanzee) |
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TMEM213 (Canis lupus familiaris - dog) |
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Tmem213 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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TMEM213 (Sus scrofa - pig) |
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D8S2279 |
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D11S3430 |
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The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
RefSeq Transcripts | NM_001085429 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_005250167 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC018663 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AI672404 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK055760 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK055841 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AW771283 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC058028 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC131697 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH236950 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH471070 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
DA626421 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_001085429 ⟹ NP_001078898 | |||||||||||||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | |||||||||||||||||||||||||||||||||||||||
Type: | CODING | |||||||||||||||||||||||||||||||||||||||
Position: |
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Sequence: |
AGAGTTGCTTTCCAGCTCCTGCAGGTGGGAGTCGACTCACCTGCAGCAGGCACTCGGCACAACThide sequence |
RefSeq Acc Id: | XM_005250167 ⟹ XP_005250224 | ||||||||||||||
RefSeq Status: | |||||||||||||||
Type: | CODING | ||||||||||||||
Position: |
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Sequence: |
GGACTACAGGGTGAGCCCCCATGCCCAACCTCAAATGCCATTTTCTTCTTGAAGCATCCCATCAhide sequence |
Protein RefSeqs | NP_001078898 | (Get FASTA) | NCBI Sequence Viewer |
XP_005250224 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | A2RRL7 | (Get FASTA) | NCBI Sequence Viewer |
AAI31698 | (Get FASTA) | NCBI Sequence Viewer | |
EAL24042 | (Get FASTA) | NCBI Sequence Viewer | |
EAW83898 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001078898 ⟸ NM_001085429 |
- Peptide Label: | precursor |
- UniProtKB: | A2RRL7 (UniProtKB/Swiss-Prot) |
- Sequence: |
MQRLPAATRATLILSLAFASLHSACSAEASSSNSSSLTAHHPDPGTLEQCLNVDFCPQAARCCRhide sequence |
RefSeq Acc Id: | XP_005250224 ⟸ XM_005250167 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A2RRL7 (UniProtKB/Swiss-Prot) |
- Sequence: |
MVFPPNTQHKFTSGRVAFQLLQVGVDSPAAGTRHNSAGPAHLHRALSTASSMQRLPAATRATLIhide sequence |
RGD ID: | 7212027 | |||||||||
Promoter ID: | EPDNEW_H11759 | |||||||||
Type: | initiation region | |||||||||
Name: | TMEM213_1 | |||||||||
Description: | transmembrane protein 213 | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | Single-end sequencing. | |||||||||
Position: |
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Name | Type | Condition(s) | Position(s) | Clinical significance |
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 | copy number gain | Cleft palate, isolated [RCV000050876]|See cases [RCV000050876] | Chr7:129310166..159282390 [GRCh38] Chr7:128950007..159075079 [GRCh37] Chr7:128737243..158767840 [NCBI36] Chr7:7q32.1-36.3 |
pathogenic |
GRCh38/hg38 7q32.3-36.3(chr7:132850196-159325876)x3 | copy number gain | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051101]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051101]|See cases [RCV000051101] | Chr7:132850196..159325876 [GRCh38] Chr7:132534956..159118566 [GRCh37] Chr7:132185496..158811327 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 | copy number loss | Ambiguous genitalia [RCV000052250]|See cases [RCV000052250] | Chr7:53985..159282531 [GRCh38] Chr7:53985..159075220 [GRCh37] Chr7:149068..158767981 [NCBI36] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh38/hg38 7q34(chr7:138795539-140364913)x3 | copy number gain | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053550]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053550]|See cases [RCV000053550] | Chr7:138795539..140364913 [GRCh38] Chr7:138480284..140064713 [GRCh37] Chr7:138130824..139711182 [NCBI36] Chr7:7q34 |
uncertain significance |
GRCh38/hg38 7q33-36.3(chr7:136309982-159307523)x3 | copy number gain | Global developmental delay [RCV000053576]|See cases [RCV000053576] | Chr7:136309982..159307523 [GRCh38] Chr7:135994730..159100212 [GRCh37] Chr7:135645270..158792973 [NCBI36] Chr7:7q33-36.3 |
pathogenic |
GRCh38/hg38 7q32.3-36.1(chr7:132023155-149309794)x1 | copy number loss | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|See cases [RCV000054172] | Chr7:132023155..149309794 [GRCh38] Chr7:131707914..149006885 [GRCh37] Chr7:131358454..148637818 [NCBI36] Chr7:7q32.3-36.1 |
pathogenic |
GRCh38/hg38 7q33-35(chr7:135414108-144140219)x1 | copy number loss | Obesity [RCV000054173]|See cases [RCV000054173] | Chr7:135414108..144140219 [GRCh38] Chr7:135098857..143837312 [GRCh37] Chr7:134749397..143468245 [NCBI36] Chr7:7q33-35 |
pathogenic |
GRCh38/hg38 7q33-34(chr7:137741740-139688885)x1 | copy number loss | Cleft uvula [RCV000054174]|See cases [RCV000054174] | Chr7:137741740..139688885 [GRCh38] Chr7:137426486..139373631 [GRCh37] Chr7:137077026..139024171 [NCBI36] Chr7:7q33-34 |
pathogenic |
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 | copy number loss | See cases [RCV000135401] | Chr7:54185..159282390 [GRCh38] Chr7:54185..159075079 [GRCh37] Chr7:149268..158767840 [NCBI36] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh38/hg38 7q33-36.2(chr7:137751200-154815582)x3 | copy number gain | See cases [RCV000136592] | Chr7:137751200..154815582 [GRCh38] Chr7:137435946..154607292 [GRCh37] Chr7:137086486..154238225 [NCBI36] Chr7:7q33-36.2 |
pathogenic |
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 | copy number gain | See cases [RCV000136717] | Chr7:97419852..158923762 [GRCh38] Chr7:97049164..158716453 [GRCh37] Chr7:96887100..158409214 [NCBI36] Chr7:7q21.3-36.3 |
pathogenic |
GRCh38/hg38 7q33-36.3(chr7:134666829-158591882)x1 | copy number loss | See cases [RCV000138120] | Chr7:134666829..158591882 [GRCh38] Chr7:134351581..158384574 [GRCh37] Chr7:134002121..158077335 [NCBI36] Chr7:7q33-36.3 |
pathogenic |
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 | copy number gain | See cases [RCV000138847] | Chr7:121863759..159335865 [GRCh38] Chr7:121503813..159128555 [GRCh37] Chr7:121291049..158821316 [NCBI36] Chr7:7q31.32-36.3 |
pathogenic |
GRCh38/hg38 7q33-36.1(chr7:135017687-148807400)x1 | copy number loss | See cases [RCV000138903] | Chr7:135017687..148807400 [GRCh38] Chr7:134702438..148504492 [GRCh37] Chr7:134352978..148135425 [NCBI36] Chr7:7q33-36.1 |
pathogenic |
GRCh38/hg38 7q32.3-36.3(chr7:132444095-159335866)x3 | copy number gain | See cases [RCV000139654] | Chr7:132444095..159335866 [GRCh38] Chr7:132128854..159128556 [GRCh37] Chr7:131779394..158821317 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 | copy number gain | See cases [RCV000141413] | Chr7:115459015..159325817 [GRCh38] Chr7:115099069..159118507 [GRCh37] Chr7:114886305..158811268 [NCBI36] Chr7:7q31.2-36.3 |
pathogenic |
GRCh38/hg38 7q32.3-36.3(chr7:131228764-159335866)x3 | copy number gain | See cases [RCV000142802] | Chr7:131228764..159335866 [GRCh38] Chr7:130913523..159128556 [GRCh37] Chr7:130564063..158821317 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
GRCh38/hg38 7q32.3-36.3(chr7:131171478-159327017)x3 | copy number gain | See cases [RCV000143754] | Chr7:131171478..159327017 [GRCh38] Chr7:130856237..159119707 [GRCh37] Chr7:130506777..158812468 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
GRCh38/hg38 7q32.3-36.3(chr7:132438072-159327017)x3 | copy number gain | See cases [RCV000143707] | Chr7:132438072..159327017 [GRCh38] Chr7:132122831..159119707 [GRCh37] Chr7:131773371..158812468 [NCBI36] Chr7:7q32.3-36.3 |
pathogenic |
NM_020632.3(ATP6V0A4):c.-137C>T | single nucleotide variant | Distal Renal Tubular Acidosis, Recessive [RCV000277686] | Chr7:138798050 [GRCh38] Chr7:138482795 [GRCh37] Chr7:7q34 |
likely benign |
NM_020632.3(ATP6V0A4):c.-169C>T | single nucleotide variant | Distal Renal Tubular Acidosis, Recessive [RCV000332752] | Chr7:138798082 [GRCh38] Chr7:138482827 [GRCh37] Chr7:7q34 |
likely benign |
NM_020632.3(ATP6V0A4):c.-248G>A | single nucleotide variant | Distal Renal Tubular Acidosis, Recessive [RCV000329140] | Chr7:138798161 [GRCh38] Chr7:138482906 [GRCh37] Chr7:7q34 |
uncertain significance |
NM_020632.3(ATP6V0A4):c.-240C>G | single nucleotide variant | Distal Renal Tubular Acidosis, Recessive [RCV000274134] | Chr7:138798153 [GRCh38] Chr7:138482898 [GRCh37] Chr7:7q34 |
uncertain significance |
NM_020632.3(ATP6V0A4):c.-136C>T | single nucleotide variant | Distal Renal Tubular Acidosis, Recessive [RCV000353643] | Chr7:138798049 [GRCh38] Chr7:138482794 [GRCh37] Chr7:7q34 |
uncertain significance |
NM_020632.3(ATP6V0A4):c.-206G>A | single nucleotide variant | Distal Renal Tubular Acidosis, Recessive [RCV000387041] | Chr7:138798119 [GRCh38] Chr7:138482864 [GRCh37] Chr7:7q34 |
uncertain significance |
GRCh37/hg19 7q33-36.3(chr7:137589621-159119707)x3 | copy number gain | See cases [RCV000449264] | Chr7:137589621..159119707 [GRCh37] Chr7:7q33-36.3 |
pathogenic |
TMEM106B-BRAF fusion | deletion | Pleomorphic xanthoastrocytoma [RCV000454357] | Chr7:12258147..140494267 [GRCh37] Chr7:7p21.3-q34 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 | copy number loss | See cases [RCV000446044] | Chr7:43360..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7q32.3-34(chr7:131642114-139107211)x1 | copy number loss | See cases [RCV000448552] | Chr7:131642114..139107211 [GRCh37] Chr7:7q32.3-34 |
pathogenic |
GRCh37/hg19 7q33-36.3(chr7:133799185-159119707)x1 | copy number loss | See cases [RCV000448836] | Chr7:133799185..159119707 [GRCh37] Chr7:7q33-36.3 |
pathogenic |
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 | copy number gain | See cases [RCV000447709] | Chr7:98969247..159119707 [GRCh37] Chr7:7q22.1-36.3 |
pathogenic |
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358)x1 | copy number loss | See cases [RCV000447722] | Chr7:127295698..139524358 [GRCh37] Chr7:7q32.1-34 |
pathogenic |
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 | copy number gain | See cases [RCV000447956] | Chr7:128276078..159119707 [GRCh37] Chr7:7q32.1-36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) | copy number gain | See cases [RCV000510686] | Chr7:43361..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7q33-36.3(chr7:136758593-159119707)x3 | copy number gain | See cases [RCV000510490] | Chr7:136758593..159119707 [GRCh37] Chr7:7q33-36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 | copy number gain | See cases [RCV000511549] | Chr7:43361..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7q33-36.3(chr7:137917376-159119707)x1 | copy number loss | See cases [RCV000511889] | Chr7:137917376..159119707 [GRCh37] Chr7:7q33-36.3 |
pathogenic |
GRCh37/hg19 7q33-34(chr7:137434852-140349546)x3 | copy number gain | See cases [RCV000512176] | Chr7:137434852..140349546 [GRCh37] Chr7:7q33-34 |
uncertain significance |
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 | copy number gain | not provided [RCV000682911] | Chr7:98693388..159119707 [GRCh37] Chr7:7q22.1-36.3 |
pathogenic |
Single allele | complex | Renal transitional cell carcinoma [RCV000754611] | Chr7:129367205..140482957 [GRCh37] Chr7:7q32.2-34 |
likely pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 | copy number gain | not provided [RCV000746278] | Chr7:10704..159122532 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 | copy number gain | not provided [RCV000746280] | Chr7:44935..159126310 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7q34(chr7:138323516-138673567)x3 | copy number gain | not provided [RCV000747066] | Chr7:138323516..138673567 [GRCh37] Chr7:7q34 |
benign |
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 | copy number gain | not provided [RCV000848126] | Chr7:10365..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) | copy number gain | not provided [RCV000767558] | Chr7:128312450..159119220 [GRCh37] Chr7:7q32.1-36.3 |
pathogenic |
GRCh37/hg19 7q33-34(chr7:137848980-138897699)x3 | copy number gain | not provided [RCV000846058] | Chr7:137848980..138897699 [GRCh37] Chr7:7q33-34 |
uncertain significance |
GRCh37/hg19 7q33-34(chr7:137675423-139084024)x1 | copy number loss | not provided [RCV000846410] | Chr7:137675423..139084024 [GRCh37] Chr7:7q33-34 |
uncertain significance |
GRCh37/hg19 7q32.3-36.3(chr7:130592554-159119707)x3 | copy number gain | not provided [RCV000849569] | Chr7:130592554..159119707 [GRCh37] Chr7:7q32.3-36.3 |
pathogenic |
Database | Acc Id | Source(s) |
AGR Gene | HGNC:27220 | AgrOrtholog |
COSMIC | TMEM213 | COSMIC |
Ensembl Genes | ENSG00000214128 | ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Protein | ENSP00000380727 | UniProtKB/Swiss-Prot |
ENSP00000390407 | ENTREZGENE, UniProtKB/Swiss-Prot | |
ENSP00000393891 | UniProtKB/Swiss-Prot | |
ENSP00000401570 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENST00000397602 | UniProtKB/Swiss-Prot |
ENST00000413208 | UniProtKB/Swiss-Prot | |
ENST00000442682 | ENTREZGENE, UniProtKB/Swiss-Prot | |
ENST00000458494 | UniProtKB/Swiss-Prot | |
GTEx | ENSG00000214128 | GTEx |
HGNC ID | HGNC:27220 | ENTREZGENE |
Human Proteome Map | TMEM213 | Human Proteome Map |
InterPro | TMEM213 | UniProtKB/Swiss-Prot |
KEGG Report | hsa:155006 | UniProtKB/Swiss-Prot |
NCBI Gene | 155006 | ENTREZGENE |
PANTHER | PTHR36293 | UniProtKB/Swiss-Prot |
Pfam | TMEM213 | UniProtKB/Swiss-Prot |
PharmGKB | PA162406494 | PharmGKB |
UniGene | Hs.567729 | ENTREZGENE |
UniProt | A2RRL7 | ENTREZGENE, UniProtKB/Swiss-Prot |
UniProt Secondary | A4D1R3 | UniProtKB/Swiss-Prot |
C9JH49 | UniProtKB/Swiss-Prot | |
C9JX41 | UniProtKB/Swiss-Prot | |
C9K0P0 | UniProtKB/Swiss-Prot |
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More on TMEM213 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: hg19 hg38 |
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HGNC Report |
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NCBI Genome Data Viewer |
CRRD Object Information | |
CRRD ID: | 2293900 |
Created: | 2008-06-20 |
Species: | Homo sapiens |
Last Modified: | 2019-11-26 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.