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Gene: Nt5c (5', 3'-nucleotidase, cytosolic) Rattus norvegicus
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Symbol: Nt5c
Name: 5', 3'-nucleotidase, cytosolic
Description: Predicted to have 5'-nucleotidase activity; identical protein binding activity; and pyrimidine nucleotide binding activity. Predicted to be involved in dephosphorylation and pyrimidine deoxyribonucleotide catabolic process. Predicted to localize to cytosol and nucleus. Orthologous to human NT5C (5', 3'-nucleotidase, cytosolic); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; INTERACTS WITH 3-chloropropane-1,2-diol; (+)-catechin (ortholog); 2,2',4,4'-Tetrabromodiphenyl ether (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5'(3')-deoxyribonucleotidase, cytosolic type; 5',3'-nucleotidase, cytosolic; 5,3-nucleotidase, cytosolic; LOC100360582; Umph2; uridine 5-monophosphate phosphohydrolase 2
Orthologs:
Homo sapiens (human) : NT5C (5', 3'-nucleotidase, cytosolic)  HGNC  Alliance
Mus musculus (house mouse) : Nt5c (5',3'-nucleotidase, cytosolic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nt5c (5', 3'-nucleotidase, cytosolic)
Pan paniscus (bonobo/pygmy chimpanzee) : NT5C (5', 3'-nucleotidase, cytosolic)
Canis lupus familiaris (dog) : NT5C (5', 3'-nucleotidase, cytosolic)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nt5c (5', 3'-nucleotidase, cytosolic)
Sus scrofa (pig) : NT5C (5', 3'-nucleotidase, cytosolic)
Chlorocebus sabaeus (African green monkey) : NT5C (5', 3'-nucleotidase, cytosolic)
Heterocephalus glaber (naked mole-rat) : Nt5c (5', 3'-nucleotidase, cytosolic)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010104,052,807 - 104,054,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,052,831 - 104,054,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,225,988 - 104,227,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,574,754 - 105,576,848 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1099,314,518 - 99,316,243 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Nt5c
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2321875
Created: 2010-05-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.