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Gene: Cdkl5 (cyclin-dependent kinase-like 5) Rattus norvegicus
Symbol: Cdkl5
Name: cyclin-dependent kinase-like 5
Description: Exhibits Rac GTPase binding activity. Involved in neuron migration; positive regulation of GTPase activity; and positive regulation of neuron projection development. Localizes to several cellular components, including dendrite; glutamatergic synapse; and postsynaptic density, intracellular component. Colocalizes with ruffle membrane. Human ortholog(s) of this gene implicated in Rett syndrome; early infantile epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; methimazole.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC100362725
Homo sapiens (human) : CDKL5 (cyclin dependent kinase like 5)  HGNC  Alliance
Mus musculus (house mouse) : Cdkl5 (cyclin-dependent kinase-like 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkl5 (cyclin dependent kinase like 5)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKL5 (cyclin dependent kinase like 5)
Canis lupus familiaris (dog) : CDKL5 (cyclin dependent kinase like 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkl5 (cyclin dependent kinase like 5)
Sus scrofa (pig) : CDKL5 (cyclin dependent kinase like 5)
Chlorocebus sabaeus (African green monkey) : CDKL5 (cyclin dependent kinase like 5)
Heterocephalus glaber (naked mole-rat) : Cdkl5 (cyclin dependent kinase like 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X35,536,396 - 35,773,204 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX35,599,258 - 35,771,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X35,864,921 - 36,102,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X55,033,499 - 55,228,646 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX34,451,035 - 34,675,154 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Cdkl5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2324133
Created: 2010-05-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.