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Gene: Kmt2d (lysine methyltransferase 2D) Rattus norvegicus
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Symbol: Kmt2d
Name: lysine methyltransferase 2D
Description: Predicted to have transcription regulatory region DNA binding activity. Predicted to be involved in several processes, including oocyte growth; positive regulation of intracellular estrogen receptor signaling pathway; and regulation of transcription, DNA-templated. Predicted to localize to the MLL3/4 complex. Human ortholog(s) of this gene implicated in Kabuki syndrome and esophagus squamous cell carcinoma. Orthologous to human KMT2D (lysine methyltransferase 2D); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH bisphenol A; glyphosate; valproic acid.
Type: protein-coding
RefSeq Status: MODEL
Also known as: histone-lysine N-methyltransferase 2D; LOC100362634; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2D; lysine (K)-specific methyltransferase 2D; Mll2; myeloid/lymphoid or mixed-lineage leukemia 2
Orthologs:
Homo sapiens (human) : KMT2D (lysine methyltransferase 2D)  HGNC  Alliance
Mus musculus (house mouse) : Kmt2d (lysine (K)-specific methyltransferase 2D)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2d (lysine methyltransferase 2D)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2D (lysine methyltransferase 2D)
Canis lupus familiaris (dog) : KMT2D (lysine methyltransferase 2D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2d (lysine methyltransferase 2D)
Sus scrofa (pig) : KMT2D (lysine methyltransferase 2D)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07140,507,137 - 140,542,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X115,017,255 - 115,057,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,601,739 - 137,639,556 (-)NCBIRGSC3.4rn4RGSC3.4
Celera7126,471,456 - 126,508,631 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Kmt2d
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2324324
Created: 2010-05-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.