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Gene: Kmt2d (lysine methyltransferase 2D) Rattus norvegicus
Symbol: Kmt2d
Name: lysine methyltransferase 2D
CRRD ID: 2324324
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including histone H3-K4 methylation; positive regulation of intracellular estrogen receptor signaling pathway; and regulation of transcription, DNA-templated. Predicted to localize to MLL3/4 complex. Human ortholog(s) of this gene implicated in Kabuki syndrome and esophagus squamous cell carcinoma. Orthologous to human KMT2D (lysine methyltransferase 2D); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH bisphenol A; glyphosate; valproic acid.
Type: protein-coding
RefSeq Status: MODEL
Also known as: histone-lysine N-methyltransferase 2D; LOC100362634; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2D; lysine (K)-specific methyltransferase 2D; Mll2; myeloid/lymphoid or mixed-lineage leukemia 2
Homo sapiens (human) : KMT2D (lysine methyltransferase 2D)  HGNC  Alliance
Mus musculus (house mouse) : Kmt2d (lysine (K)-specific methyltransferase 2D)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2d (lysine methyltransferase 2D)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2D (lysine methyltransferase 2D)
Canis lupus familiaris (dog) : KMT2D (lysine methyltransferase 2D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2d (lysine methyltransferase 2D)
Sus scrofa (pig) : KMT2D (lysine methyltransferase 2D)
Chlorocebus sabaeus (African green monkey) : KMT2D (lysine methyltransferase 2D)
Heterocephalus glaber (naked mole-rat) : Kmt2d (lysine methyltransferase 2D)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07140,507,137 - 140,542,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,489,492 - 140,546,908 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,017,255 - 115,057,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,601,739 - 137,639,556 (-)NCBIRGSC3.4rn4RGSC3.4
Celera7126,471,456 - 126,508,631 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Kmt2d
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2324324
Created: 2010-05-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.