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Gene: Otulin (OTU deubiquitinase with linear linkage specificity) Rattus norvegicus
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Symbol: Otulin
Name: OTU deubiquitinase with linear linkage specificity
Description: Predicted to have thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in several processes, including nucleotide-binding activity oligomerization domain containing 2 signaling pathway; protein linear deubiquitination; and regulation of signal transduction. Predicted to colocalize with LUBAC complex. Human ortholog(s) of this gene implicated in otulipenia. Orthologous to human OTULIN (OTU deubiquitinase with linear linkage specificity); INTERACTS WITH acrylamide; bisphenol A; 17beta-hydroxy-5alpha-androstan-3-one (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Fam105b; family with sequence similarity 105, member B; hypothetical protein LOC100362554; LOC100362554; ubiquitin thioesterase otulin
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0280,267,724 - 80,293,204 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl280,269,587 - 80,293,181 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0299,932,239 - 99,958,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4279,431,094 - 79,454,752 (-)NCBIRGSC3.4rn4RGSC3.4
Celera273,945,074 - 73,970,536 (-)NCBICelera
Cytogenetic Map2q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Otulin
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2324500
Created: 2010-05-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.