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Gene: Cftr (CF transmembrane conductance regulator) Rattus norvegicus
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Symbol: Cftr
Name: CF transmembrane conductance regulator
Description: Predicted to have several functions, including PDZ domain binding activity; Sec61 translocon complex binding activity; and transmembrane transporter activity. Involved in several processes, including anion transport; cellular response to anoxia; and regulation of epithelial cell differentiation. Localizes to several cellular components, including apical plasma membrane; basolateral plasma membrane; and microvillus. Colocalizes with early endosome. Used to study cystic fibrosis; duodenal ulcer; gastric ulcer; and male reproductive system disease. Biomarker of autosomal recessive polycystic kidney disease; cholestasis; and salpingitis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); cystic fibrosis; and lung disease (multiple). Orthologous to human CFTR (CF transmembrane conductance regulator); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 17beta-estradiol; 3',5'-cyclic AMP; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog (human); LOC500041; RGD1561193; similar to cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
Orthologs:
Homo sapiens (human) : CFTR (CF transmembrane conductance regulator)  HGNC  Alliance
Mus musculus (house mouse) : Cftr (cystic fibrosis transmembrane conductance regulator)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cftr (CF transmembrane conductance regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CFTR (CF transmembrane conductance regulator)
Canis lupus familiaris (dog) : CFTR (CF transmembrane conductance regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cftr (CF transmembrane conductance regulator)
Sus scrofa (pig) : CFTR (CF transmembrane conductance regulator)
Chlorocebus sabaeus (African green monkey) : CFTR (CF transmembrane conductance regulator)
Heterocephalus glaber (naked mole-rat) : Cftr (CF transmembrane conductance regulator)
more info ...
Allele / Splice: Cftrem1Sage  
Genetic Models: SD-Cftrem1Sage-/- SD-Cftrem1Sage+/-
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0442,693,263 - 42,860,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl442,692,836 - 42,860,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0442,281,040 - 42,448,571 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,874,852 - 44,041,870 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1444,147,212 - 44,195,889 (+)NCBI
Celera441,826,966 - 41,988,614 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations