Gene: Cftr (cystic fibrosis transmembrane conductance regulator) Rattus norvegicus
Symbol: Cftr
Name: cystic fibrosis transmembrane conductance regulator
Description: Predicted to have several functions, including PDZ domain binding activity, Sec61 translocon complex binding activity, and transmembrane transporter activity; involved in several processes, including animal organ development, anion transport, and regulation of cell development; localizes to several cellular components, including the apical plasma membrane, basolateral plasma membrane, and intracellular organelle; colocalizes with the early endosome; used to study cystic fibrosis, duodenal ulcer, and gastric ulcer; biomarker of autosomal recessive polycystic kidney disease, cholestasis, and salpingitis; orthologous to human CFTR (cystic fibrosis transmembrane conductance regulator); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 17beta-estradiol; 3',5'-cyclic AMP; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
Also known as: ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog (human); LOC500041; RGD1561193; similar to cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
Allele / Splice: Cftrem1Sage  
Genetic Models: SD-Cftrem1Sage-/- SD-Cftrem1Sage+/-
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0442,693,263 - 42,860,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0442,281,040 - 42,448,571 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4443,874,852 - 44,041,870 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1444,147,212 - 44,195,889 (+)NCBI
Celera441,826,966 - 41,988,614 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)