Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Chrm3 (cholinergic receptor, muscarinic 3) Rattus norvegicus
Analyze
Symbol: Chrm3
Name: cholinergic receptor, muscarinic 3
Description: Exhibits G protein-coupled acetylcholine receptor activity and acetylcholine binding activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and positive regulation of vascular smooth muscle contraction. Localizes to several cellular components, including axon terminus; glutamatergic synapse; and integral component of synaptic membrane. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cholinergic receptor, muscarinic 3, cardiac; muscarinic acetylcholine receptor M3
Orthologs:
Homo sapiens (human) : CHRM3 (cholinergic receptor muscarinic 3)  HGNC  Alliance
Mus musculus (house mouse) : Chrm3 (cholinergic receptor, muscarinic 3, cardiac)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrm3 (cholinergic receptor muscarinic 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRM3 (cholinergic receptor muscarinic 3)
Canis lupus familiaris (dog) : CHRM3 (cholinergic receptor muscarinic 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrm3 (cholinergic receptor muscarinic 3)
Sus scrofa (pig) : CHRM3 (cholinergic receptor muscarinic 3)
Chlorocebus sabaeus (African green monkey) : CHRM3 (cholinergic receptor muscarinic 3)
Heterocephalus glaber (naked mole-rat) : Chrm3 (cholinergic receptor muscarinic 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01763,990,599 - 64,463,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1763,990,599 - 63,994,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01765,753,665 - 66,217,211 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41771,214,906 - 71,218,463 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11771,081,449 - 71,229,296 (+)NCBI
Celera1760,109,356 - 60,562,246 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Chrm3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2343
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.