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Gene: Chrm4 (cholinergic receptor, muscarinic 4) Rattus norvegicus
Symbol: Chrm4
Name: cholinergic receptor, muscarinic 4
Description: Exhibits guanyl-nucleotide exchange factor activity. Involved in response to organic substance. Localizes to several cellular components, including glutamatergic synapse; integral component of synaptic membrane; and neuronal cell body. Colocalizes with sarcolemma. Biomarker of congestive heart failure. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cholinergic receptor, muscarin 4; M4; muscarinic acetylcholine receptor M4
Homo sapiens (human) : CHRM4 (cholinergic receptor muscarinic 4)  HGNC  Alliance
Mus musculus (house mouse) : Chrm4 (cholinergic receptor, muscarinic 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrm4 (cholinergic receptor muscarinic 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRM4 (cholinergic receptor muscarinic 4)
Canis lupus familiaris (dog) : CHRM4 (cholinergic receptor muscarinic 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrm4 (cholinergic receptor muscarinic 4)
Sus scrofa (pig) : CHRM4 (cholinergic receptor muscarinic 4)
Chlorocebus sabaeus (African green monkey) : CHRM4 (cholinergic receptor muscarinic 4)
Heterocephalus glaber (naked mole-rat) : Chrm4 (cholinergic receptor muscarinic 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0380,833,272 - 80,841,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,833,272 - 80,841,006 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,531,619 - 87,539,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,301,988 - 76,309,729 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1376,203,520 - 76,206,094 (+)NCBI
Celera377,096,073 - 77,103,815 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Chrm4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2344
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.