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Gene: Chrna3 (cholinergic receptor nicotinic alpha 3 subunit) Rattus norvegicus
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Symbol: Chrna3
Name: cholinergic receptor nicotinic alpha 3 subunit
Description: Exhibits acetylcholine binding activity; acetylcholine receptor activity; and acetylcholine-gated cation-selective channel activity. Involved in several processes, including acetylcholine receptor signaling pathway; regulation of synaptic vesicle exocytosis; and response to nicotine. Localizes to several cellular components, including cholinergic synapse; dopaminergic synapse; and integral component of plasma membrane. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; INTERACTS WITH (S)-anabasine; (S)-nicotine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Acetylcholine receptor alpha 3 (neuronal nicotine); acetylcholine receptor alpha3; cetylcholine receptor alpha 3 (neuronal nicotine); cholinergic receptor nicotinic alpha polypeptide 4; cholinergic receptor, nicotinic, alpha 3; cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; neuronal acetylcholine receptor subunit alpha-3
Orthologs:
Homo sapiens (human) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)  HGNC  Alliance
Mus musculus (house mouse) : Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Canis lupus familiaris (dog) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
Sus scrofa (pig) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Chlorocebus sabaeus (African green monkey) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Heterocephalus glaber (naked mole-rat) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
more info ...
Allele / Splice: Chrna3em1Mcwi   Chrna3em9Mcwi  
Genetic Models: LEW-Chrna3em9Mcwi LEW-Chrna3em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0859,594,007 - 59,607,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,592,403 - 59,607,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,176,165 - 58,189,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,570,223 - 58,583,594 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1858,588,997 - 58,602,801 (-)NCBI
Celera854,888,972 - 54,929,562 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Chrna3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2345
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.