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Gene: Chrna3 (cholinergic receptor nicotinic alpha 3 subunit) Rattus norvegicus
Symbol: Chrna3
Name: cholinergic receptor nicotinic alpha 3 subunit
Description: Exhibits acetylcholine binding activity; acetylcholine receptor activity; and acetylcholine-gated cation-selective channel activity. Involved in several processes, including acetylcholine receptor signaling pathway; regulation of synaptic vesicle exocytosis; and response to nicotine. Localizes to several cellular components, including cholinergic synapse; dopaminergic synapse; and integral component of plasma membrane. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; INTERACTS WITH (S)-anabasine; (S)-nicotine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
Also known as: Acetylcholine receptor alpha 3 (neuronal nicotine); acetylcholine receptor alpha3; cetylcholine receptor alpha 3 (neuronal nicotine); cholinergic receptor nicotinic alpha polypeptide 4; cholinergic receptor, nicotinic, alpha 3; cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; neuronal acetylcholine receptor subunit alpha-3
Homo sapiens (human) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)  HGNC  Alliance
Mus musculus (house mouse) : Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Canis lupus familiaris (dog) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
Sus scrofa (pig) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Chlorocebus sabaeus (African green monkey) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Heterocephalus glaber (naked mole-rat) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
more info ...
Allele / Splice: Chrna3em1Mcwi   Chrna3em9Mcwi  
Genetic Models: LEW-Chrna3em9Mcwi LEW-Chrna3em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0859,594,007 - 59,607,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,592,403 - 59,607,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,176,165 - 58,189,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,570,223 - 58,583,594 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1858,588,997 - 58,602,801 (-)NCBI
Celera854,888,972 - 54,929,562 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Chrna3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2345
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.