Gene: Grem1 (gremlin 1, DAN family BMP antagonist) Rattus norvegicus
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Symbol: Grem1
Name: gremlin 1, DAN family BMP antagonist
Description: Predicted to have several functions, including BMP binding activity, molecular function regulator, and protein homodimerization activity; involved in several processes, including apoptotic process, negative regulation of cell growth, and negative regulation of monocyte chemotaxis; localizes to the cell surface and extracellular space; orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cktsf1b1; cysteine knot superfamily 1, BMP antagonist 1; down-regulated in mos-transformed cells; drm; gremlin 1; gremlin 1 homolog, cysteine knot superfamily; gremlin 1 homolog, cysteine knot superfamily (Xenopus laevis); gremlin 1, cysteine knot superfamily, homolog; gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis); gremlin-1
Orthologs:
Homo sapiens (human) : GREM1 (gremlin 1, DAN family BMP antagonist)  HGNC  Alliance
Mus musculus (house mouse) : Grem1 (gremlin 1, DAN family BMP antagonist)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grem1 (gremlin 1, DAN family BMP antagonist)
Pan paniscus (bonobo/pygmy chimpanzee) : GREM1 (gremlin 1, DAN family BMP antagonist)
Canis lupus familiaris (dog) : GREM1 (gremlin 1, DAN family BMP antagonist)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grem1 (gremlin 1, DAN family BMP antagonist)
Sus scrofa (pig) : GREM1 (gremlin 1, DAN family BMP antagonist)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03105,203,309 - 105,214,989 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03111,779,965 - 111,791,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4399,597,201 - 99,608,935 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1399,493,630 - 99,505,363 (-)NCBI
Celera399,483,712 - 99,495,442 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Grem1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2359
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.