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Gene: Cpt1a (carnitine palmitoyltransferase 1A) Rattus norvegicus
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Symbol: Cpt1a
Name: carnitine palmitoyltransferase 1A
Description: Exhibits carnitine O-palmitoyltransferase activity and identical protein binding activity. Involved in several processes, including positive regulation of fatty acid beta-oxidation; protein homooligomerization; and regulation of insulin secretion. Localizes to the integral component of mitochondrial outer membrane. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A); PARTICIPATES IN carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; fatty acid beta degradation pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: carnitine O-palmitoyltransferase 1, liver isoform; carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1 alpha liver isoform; Carnitine palmitoyltransferase 1 alpha, liver isoform; Carnitine palmitoyltransferase 1, liver; carnitine palmitoyltransferase 1A liver; carnitine palmitoyltransferase 1a, liver; CPT I; CPT-Ia; CPT1-L; CPTI-L
Orthologs:
Homo sapiens (human) : CPT1A (carnitine palmitoyltransferase 1A)  HGNC  Alliance
Mus musculus (house mouse) : Cpt1a (carnitine palmitoyltransferase 1a, liver)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cpt1a (carnitine palmitoyltransferase 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : CPT1A (carnitine palmitoyltransferase 1A)
Canis lupus familiaris (dog) : CPT1A (carnitine palmitoyltransferase 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cpt1a (carnitine palmitoyltransferase 1A)
Sus scrofa (pig) : CPT1A (carnitine palmitoyltransferase 1A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01218,568,157 - 218,629,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01225,436,031 - 225,497,586 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,852,800 - 205,912,972 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11206,006,198 - 206,066,422 (+)NCBI
Celera1198,121,771 - 198,182,510 (+)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cpt1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 2396
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-09-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.